Table 3 Summary of changes in gene expression for the core set of HDAC inhibitor regulated genes
| Â | Â | Â | HCT116 | HT29 | ||
|---|---|---|---|---|---|---|
Accession # | Gene Symbol | Gene Name | Fold Change* | Fold Change* | ||
Induced | Â | Â | LBH589 | VOR | LBH589 | VOR |
NM_182908.3 | DHRS2 | Dehydrogenase/reductase member 2 | 4.78 | 4.05 | 4.37 | 4.21 |
NM_183376.1 | ARRDC4 | Arrestin domain containing 4 | 4.15 | 3.35 | 2.21 | 2.14 |
NM_138720.1 | HIST1H2BD | Histone 1, H2bd | 3.35 | 2.53 | 3.44 | 3.33 |
NM_005952.2 | MT1X | Metallothionein 1X | 2.87 | 2.37 | 3.66 | 3.31 |
NM_005950.1 | MT1G | Metallothionein 1G | 2.78 | 2.08 | 3.30 | 3.00 |
NM_015149.2 | RGL1 | Tal guanine nucleotide dissociation stimulator-like 1 | 2.52 | 1.56 | 3.12 | 3.03 |
Repressed | Â | Â | Â | Â | Â | Â |
NM_001071.1 | TYMS | Thymidylate synthase | -3.88 | -2.74 | -3.82 | -3.59 |
NM_145810.1 | CDCA7 | Cell division cycle associated 7 | -3.06 | -2.08 | -2.59 | -2.42 |
NM_080911.1 | UNG | Uracil-DNA glycosylase | -2.54 | -1.55 | -2.58 | -2.79 |
NM_003998.2 | NFkB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | -2.55 | -2.04 | -1.65 | -1.8 |
NM_001025242.1 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -1.97 | -1.65 | -2.15 | -2.08 |