A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival

Table 1 GO-analysis of gene expression alterations over time

GO term annotation	Category	HT p-value	Enrichment
kinase binding	MF	0.0000013	4/11
histone acetyltransferase activity	MF	0.0000017	6/30
glutathione transferase activity	MF	0.0000064	6/36
BMP signalling pathway	BP	0.0000081	4/15
Oxidoreductase activity	MF	0.0000118	41/1019
DNA replication initiation	BP	0.0000295	4/19
Acyltransferase activity	MF	0.0000537	14/224
magnesium ion binding	MF	0.0000696	25/554
*negative regulation of cell proliferation*	BP	0.0002658	10/152
*cell cycle*	BP	0.0004519	27/694
lipoprotein metabolic process	BP	0,0004900	3/19
transcription factor binding	MF	0.0006180	9/142
lipid transport	BP	0.0007125	7/96
glutathione metabolic process	BP	0.0010504	3/23
fatty acid metabolic process	BP	0.0011307	7/103
cytoskeletal protein binding	MF	0.0012260	6/81
protein amino acid dephosphorylation	BP	0.0012779	12/241
regulation of translational initiation	BP	0.0016908	3/26
*positive regulation of I-κB kinase/NF-κB* cascade	BP	0.0019357	5/65
Phosphoprotein phosphatase activity	MF	0.0021059	12/255
*induction of apoptosis*	BP	0.0022511	8/141
cell division	BP	0.0023318	14/321
positive regulation of transcription from RNA polymerase II promoter	BP	0.0024536	11/229
transcription regulator activity	MF	0.0026217	14/325
nucleotide metabolic process	BP	0.0029513	4/49
electron transport	BP	0.0031794	23/645
transcription coactivator activity	MF	0.0032915	7/122
ubiquitin-protein ligase activity	MF	0.0034684	11/239
negative regulation of transcription	BP	0.0035622	8/151

The list of 925 significantly altered genes was submitted to GO analysis elucidating over-represented GO terms. HT p-value represents the hypergeometric test p-value score for each GO term. Enrichment represents the ratio of the number of times a GO term occurs in the significant gene list to the number of times this GO term exists in the list of the entire array. Selected categories for further analysis are shown in bold, italics.

ISSN: 1755-8794