Genes that were differentially regulated between fasting and feeding at the 6 hour time point continue to be regulated at the 10 hour time point for the fasted arm, but not for the fed arm. The left panels show that the 6 hour to 10 hour changes for the fast-fed signature in the fed arm mostly center around zero; the right panels show significant changes for the fast-fed signature in the fasted arm. Subjects in all arms were fed 30 minutes after the 6 hour biopsy time point. Y-axis: number of genes. X-axis: Fold changes (log10) between 6 hour and 10 hour time points.