Table 3 Selected Major Genes and Disease Phenotypes
Gene | Â | Gene | Â |
|---|---|---|---|
APOE | ALZHEIMER DISEASE (70) | VDR | PROSTATIC NEOPLASMS (10) |
| Â | CORONARY DISEASE (8) | Â | OSTEOPOROSIS, POSTMENOPAUSAL (8) |
| Â | CARDIOVASCULAR DISEASES (7) | Â | BREAST NEOPLASMS (7) |
| Â | MYOCARDIAL INFARCTION (6) | Â | DIABETES MELLITUS, TYPE 1 (6) |
| Â | DIABETES MELLITUS, TYPE 2 (6) | Â | OSTEOPOROSIS (6) |
ACE | HYPERTENSION (47) | MTHFR | NEURAL TUBE DEFECTS (6) |
| Â | DIABETES MELLITUS, TYPE 2 (25) | Â | COLORECTAL NEOPLASMS (5) |
| Â | MYOCARDIAL INFARCTION (17) | Â | DIABETES MELLITUS, TYPE 2 (5) |
| Â | CORONARY DISEASE (16) | Â | ESOPHAGEAL NEOPLASMS (5) |
| Â | DIABETIC NEPHROPATHIES (15) | Â | ADENOCARCINOMA (4) |
HLA-DQB1 | DIABETES MELLITUS, TYPE 1 (30) | CYP17A1 | BREAST NEOPLASMS (10) |
| Â | PAPILLOMAVIRUS INFECTIONS (7) | Â | PROSTATIC NEOPLASMS (9) |
| Â | CELIAC DISEASE (6) | Â | PROSTATIC HYPERPLASIA (4) |
| Â | AUTOIMMUNE DISEASES (5) | Â | OSTEOPOROSIS, POSTMENOPAUSAL (3) |
| Â | TUBERCULOSIS, PULMONARY (5) | Â | ENDOMETRIAL NEOPLASMS (2) |
DRD2 | ALCOHOLISM (17) | ADRB2 | ASTHMA (12) |
| Â | SCHIZOPHRENIA (14) | Â | OBESITY (10) |
| Â | PERSONALITY DISORDER (2) | Â | HYPERTENSION (8) |
| Â | DEPRESSIVE DISORDER (2) | Â | DIABETES MELLITUS, TYPE 2 (4) |
| Â | DYSKINESIA, DRUG INDUCED (2) | Â | BRONCHIAL HYPERREACTIVITY (4) |
PPARG | DIABETES MELLITUS, TYPE 2 (18) | NOS3 | HYPERTENSION (20) |
| Â | OBESITY (11) | Â | MYOCARDIAL INFARCTION (18) |
| Â | DIABETES MELLITUS (6) | Â | CORONARY ARTERY DISEASE (15) |
| Â | INSULIN RESISTANCE (4) | Â | CORONARY DISEASE (12) |
| Â | GLUCOSE INTOLERANCE (2) | Â | DIABETES MELLITUS, TYPE 2 (10) |