Table 5 Selected Mouse Genes-Disease Phenotypes
Mouse Gene Sym. | Human Ortholog Gene Sym. | Mouse Phenotype 1 | Mouse Phenotype 2 | Mouse Phenotype 3 | Mouse Phenotype 4 | Mouse Phenotype 5 |
|---|---|---|---|---|---|---|
A4galt | A4GALT | abnormal induced morb./mort. | abnormal resp./metab. to xenobiotics | life span-post-weaning/aging | homeostasis/metab. phenotype | Â |
Abca2 | ABCA2 | tremors | decreased body weight | behavior/neurological phenotype | hyperactivity | increased startle reflex |
Abcc2 | ABCC2 | abnormal blood chemistry | abnormal liver physiology | abnormal urine chemistry | abnormal kidney physiology | Abn. resp./metabolism to xenobiotics |
Abi2 | ABI2 | abn. corpus callosum morph. | abnormal cerebral cortex morph. | abnormal hippocampus morph. | abnormal dentate gyrus morph. | microphthalmia |
Acaca | ACACA | abnormal liver physiology | abnormal lipid level | incr. circulating free fatty acid level | hyperglycemia | embryonic growth arrest |
Acads | ACADS | hypoglycemia | behavior/neurological phenotype | abnormal drinking behavior | abnormal food preference | abnormal urine chemistry |
Accn1 | ACCN1 | retinal degeneration | vision/eye phenotype | abnormal eye electrophysiology | Â | Â |
Adad1 | ADAD1 | impaired fertilization | male infertility | asthenozoospermia | oligozoospermia | reproductive system phenotype |
Adam23 | ADAM23 | tremors | behavior/neurological phenotype | ataxia | postnatal lethality | lethality-postnatal |
Adarb1 | ADARB1 | behavior/neurological phenot. | seizures | postnatal lethality | behavior/neurological phenotype | normal phenotype |
Adipoq | ADIPOQ | vasculature congestion | increased body weight | decreased body weight | abnormal CNS syn. transmission | abnormal coat appearance |
Adora1 | ADORA1 | behavior/neurological phenot. | increased anxiety-related response | abnormal body temperature regulation | abnormal angiogenesis | abnormal nervous system electrophys. |
Ager | AGER | increased bone density | abnormal cancellous bone morph. | abnormal blood chemistry | reproductive system phenotype | abnormal cell proliferation |
Akap1 | AKAP1 | reduced female fertility | decreased litter size | abnormal female meiosis | increased cholesterol level | Â |
Apoc1 | APOC1 | abnormal circ. cholesterol level | abnormal lipid level | increased circulating triglyceride level | abnormal immune sys. Morph. | abnormal bile composition |
B2m | B2M | decreased hematocrit | abnormal interleukin-10 physiology | rectal prolapse | abnormal dorsal root gang. morph. | enlarged spleen |
Bax | BAX | enlarged spleen | increased thymocyte number | abnormal motor neuron morph. | short snout | abnormal sympathetic neuron morph. |
Bcl2 | BCL2 | small ears | absent melanin granules in hair follicle | abnormal snout morph. | herniated abdominal wall | abnormal small intestine morph. |
Bmp1 | BMP1 | abnormal heart morph. | abnormal aorta morph. | abnormal ventricular septum morph. | abnormal awl hair | prenatal lethality |
Brca1 | BRCA1 | abnormal cell death | increased cell proliferation | decreased cell proliferation | decreased anxiety-related resp. | kinked tail |
Capn10 | CAPN10 | abnormal pancreas physiology | endocrine/exocrine gland phenotype | digestive/alimentary phenotype | decreased inflammatory response | Â |
Casp1 | CASP1 | abnormal apoptosis | abnormal induced morbidity/mortality | abnormal inflammatory response | decr. suscep. to endotoxin shock | tumorigenesis |
Ccr4 | CCR4 | immune system phenotype | decreased tumor necrosis factor secr. | decreased interleukin-1 beta secretion | abnormal induced morbid./mort. | Â |
Dusp1 | DUSP1 | thick alveolar septum | abnormal circ. alanine transaminase | hypotension | increased thymocyte number | lung inflammation |
E2f1 | E2F1 | abnormal cell death | decreased salivation | enlarged thymus | pale liver | exencephaly |
Epo | EPO | abnormal erythropoiesis | abnormal pericardium morph. | small liver | postnatal growth retardation | abnormal hepatocyte morph. |
Ercc4 | ERCC4 | abnormal cell content/morph. | abnormal liver morph. | decreased body weight | absent blood islands | liver/biliary system phenotype |
F5 | F5 | behavior/neurological phenot. | abnormal somite development | abnormal yolk sac morph. | increased suscep. to bact. Infect. | hemorrhage |
Fcgr1 | FCGR1A | impaired macrophage phagocyt. | abnormal inflammatory response | decreased inflammatory response | abnormal yolk sac morph. | abnormal cell-mediated immunity |
Foxo1 | FOXO1 | absent organized vascular net. | abnormal looping morphogenesis | abnormal vasculature | exencephaly | absent vitelline blood vessels |
Gadd45a | GADD45A | decreased leukocyte cell num. | increased cell proliferation | increased thymocyte number | postnatal lethality | skin irradiation sensitivity |
Gap43 | GAP43 | decreased body weight | abnormal optic nerve innervation | absent optic tract | abnormal erythropoiesis | nervous system phenotype |
Gata1 | GATA1 | decreased hematocrit | abnormal thrombopoiesis | extramedullary hematopoiesis | overexpanded resp. alveoli | liver hypoplasia |
Grin1 | GRIN1 | abn. trigeminal nerve morph. | atelectasis | lung hemorrhage | abnormal tympanic ring morph. | decreased body weight |
Hoxa1 | HOXA1 | small ears | abnormal inner ear morph. | abnormal malleus morph. | increased susceptibility to injury | abnormal cochlea morph. |
Hspa1a | HSPA1A | decreased body weight | increased cell. Sens. to gamma-irrad. | chromosome breakage | increased body weight | homeostasis/metabolism phenotype |
Icam1 | ICAM1 | increased leukocyte cell number | increased neutrophil cell number | increased monocyte cell number | abnormal spatial learning | abnormal retina morph. |
Igbp1 | IGBP1 | decreased thymocyte number | behavior/neurological phenotype | abnormal cued conditioning behavior | intestinal ulcer | abnormal thymus lobule morph. |