Table 7 Selected Human Disease Phenotypes (MeSH) and Gene counts, positive associations
Disease Mesh Term | Gene Rank 1 | Gene Rank 2 | Gene Rank 3 | Gene Rank 4 | Gene Rank 5 | Gene Rank 6 | Gene Rank 7 | Gene Rank 8 |
|---|---|---|---|---|---|---|---|---|
DISEASE CLASS - CARDIOVASCULAR | Â | Â | Â | Â | Â | Â | Â | Â |
Hypertension | ACE(47) | AGT(24) | NOS3(20) | CYP11B2(18) | GNB3(18) | ADD1(16) | AGTR1(12) | ADRB2(8) |
Myocardial Infarction | NOS3(18) | ACE(17) | SERPINE1(11) | ITGA2(7) | LPL(6) | APOE(6) | GP1BA(5) | F7(5) |
Coronary Disease | ACE(16) | NOS3(12) | PON1(11) | APOB(11) | APOE(8) | LPL(7) | AGT(6) | SERPINE1(6) |
Coronary Artery Disease | NOS3(15) | PON1(9) | ACE(7) | APOA5(6) | APOE(5) | AGT(4) | ABCA1(4) | APOA1(4) |
Hypertrophy, Left Ventricular | ACE(15) | GNB3(3) | AGTR2(2) | EDN1(2) | TNNT2(2) | NOS3(2) | ENPP1(1) | ACE2(1) |
Venous Thrombosis | F5(8) | F2(5) | SERPINE1(4) | MTHFR(3) | ABO(2) | F8(2) | JAK2(2) | PROCR(2) |
Cardiovascular Diseases | APOE(7) | CETP(6) | ACE(5) | NOS3(5) | PON1(4) | APOA5(4) | APOC3(4) | SERPINE1(3) |
Myocardial Ischemia | ACE(6) | LPL(5) | NOS3(2) | ITGB3(2) | APOB(2) | AGT(1) | AGTR1(1) | SELPLG(1) |
Arteriosclerosis | ACE(5) | CD14(4) | PON1(3) | FGB(3) | MTHFR(3) | NOS3(3) | APOE(3) | TLR4(2) |
Cardiomyopathies | TTR(5) | HFE(1) | APOA1(1) | HLADQB1(1) | SOD2(1) | CCR2(1) | SELE(1) | MMP9(1) |
Heart Failure | ADRA2C(5) | ADRB1(5) | ACE(3) | NOS3(3) | ADRB2(3) | AMPD1(2) | SCNN1B(1) | EDN1(1) |
DISEASE CLASS - DIGESTIVE SYS. DISEASES | Â | Â | Â | Â | Â | Â | Â | Â |
Pancreatitis | SPINK1(15) | CFTR(5) | PRSS1(3) | HLA-DRB1(2) | HLA-A(1) | TLR4(1) | UGT1A7(1) | KRT8(1) |
Cystic Fibrosis | CFTR(10) | NOS1(2) | SERPINA1(2) | SPINK1(1) | CAPN10(1) | SFTPA2(1) | GCLC(1) | FCGR2A(1) |
Celiac Disease | HLADQB1(6) | CTLA4(6) | HLADQA1(4) | TNF(2) | PTPN22(1) | IFNG(1) | TIPARP(1) | IL21(1) |
Crohn Disease | IL23R(6) | NOD2(5) | TNF(5) | ABCB1(4) | CD14(4) | IBD5(3) | DLG5(3) | MIF(3) |
Liver Cirrhosis, Alcoholic | ALDH2(6) | ACE(1) | TNF(1) | SOD2(1) | ADH1C(1) | ADH1B(1) | DRD2(1) | CYP2E1(1) |
Colitis, Ulcerative | ABCB1(5) | IL23R(5) | TNF(4) | CD14(4) | TLR4(3) | ICAM1(3) | IL1RN(3) | CTLA4(3) |
Gastritis, Atrophic | MPO(3) | TLR4(1) | IL13(1) | PTPN11(1) | TNF(1) | ABO(1) | CMA1(1) | IL1B(1) |
Inflammatory Bowel Diseases | TNF(3) | ABCB1(3) | IL23R(3) | ITPA(2) | NOD2(2) | DLG5(2) | HP(2) | PON1(1) |
Cholangitis, Sclerosing | HLADRB1(2) | HP(2) | PTPN22(1) | MMP1(1) | HLADQA1(1) | TNF(1) | HLADQB1(1) | MMP3(1) |
DISEASE CLASS - DIS. OF ENVIRONMENTAL ORIGIN | Â | Â | Â | Â | Â | Â | Â | Â |
Alcoholism | DRD2(17) | OPRM1(9) | SLC6A4(8) | ALDH2(7) | MAOA(6) | GABRA2(4) | NPY(4) | ADH1B(3) |
DNA Damage | XRCC1(7) | TP53(3) | CYP1A1(3) | GSTM1(3) | OGG1(3) | LIG4(2) | APEX1(2) | BRCA2(2) |
Substance-Related Disorders | SLC6A4(5) | OPRM1(5) | DRD4(4) | DRD5(2) | BDNF(2) | ADH4(2) | CNR1(2) | DRD2(2) |
Fractures, Bone | ESR1(4) | ESR2(2) | COL1A1(2) | CYP19A1(1) | IGF1(1) | TNFRSF11B(1) | P2RX7(1) | TGFB1(1) |
Tobacco Use Disorder | CYP2A6(3) | SLC6A3(3) | CHRNA4(2) | TH(2) | BDNF(1) | PPP1R1B(1) | SLC18A2(1) | PTEN(1) |
Cocaine-Related Disorders | PDYN(2) | HOMER1(1) | TTC12(1) | ANKK1(1) | DBH(1) | GSTP1(1) | OPRM1(1) | Â |
Heroin Dependence | OPRM1(2) | BDNF(1) | OPRD1(1) | SLC6A4(1) | COMT(1) | MAOA(1) | Â | Â |
Spinal Fractures | COL1A1(2) | CYP19A1(1) | TNFRSF11B(1) | GC(1) | PLXNA2(1) | AR(1) | NOS3(1) | Â |
DISEASE CLASS - IMMUNE SYSTEM | Â | Â | Â | Â | Â | Â | Â | Â |
Autoimmune Diseases | CTLA4(8) | HLADQB1(5) | HLADRB1(4) | HLADQA1(4) | PTPN22(2) | HLA-A(2) | CYP2D6(2) | CIITA(2) |
Hypersensitivity, Immediate | IL4R(8) | IL13(4) | CD14(4) | IL4(2) | SERPINE1(2) | CCL5(2) | NOS2A(2) | CTLA4(2) |
Graft vs Host Disease | IFNG(3) | TNF(2) | TLR4(1) | NOD2(1) | HLA-DPB1(1) | HLA-A(1) | IL10(1) | IL1R1(1) |
Hypersensitivity | IL4(3) | STAT6(3) | IL4R(2) | IFNG(1) | IFNGR1(1) | TLR2(1) | FADS1(1) | IL13(1) |
Antiphospholipid Syndrome | F2(2) | SELPLG(1) | SERPINE1(1) | FCGR2A(1) | HLADMA(1) | Â | Â | Â |
Food Hypersensitivity | IL4(1) | IL4R(1) | STAT6(1) | IL13(1) | HLADQB1(1) | CD14(1) | Â | Â |
DISEASE CLASS - MENTAL DISORDERS | Â | Â | Â | Â | Â | Â | Â | Â |
Schizophrenia | DRD3(24) | HTR2A(18) | DRD2(14) | COMT(10) | HTR2C(8) | BDNF(8) | DRD4(8) | NOTCH4(8) |
Attention Deficit Disorder with Hyperactivity | DRD4(17) | SLC6A3(7) | SLC6A4(6) | ADRA2A(4) | MAOA(3) | SNAP25(3) | SLC6A2(2) | DRD5(2) |
Depressive Disorder | SLC6A4(13) | HTR2A(4) | TPH1(3) | CYP2D6(2) | CYP2C19(2) | MAOA(2) | BDNF(2) | DRD2(2) |
Depressive Disorder, Major | SLC6A4(13) | TPH1(5) | HTR2A(4) | TPH2(3) | BDNF(2) | DRD2(2) | GNB3(2) | DTNBP1(1) |
Bipolar Disorder | SLC6A4(10) | BDNF(6) | MAOA(5) | COMT(5) | XBP1(3) | GABRA5(3) | HTR2A(3) | TPH2(3) |
Anxiety Disorders | SLC6A4(7) | MAOA(3) | PLXNA2(1) | BDNF(1) | DBI(1) | MED12(1) | GABRB3(1) | DRD2(1) |
Mood Disorders | SLC6A4(5) | DRD4(4) | CLOCK(2) | MAOA(2) | BDNF(2) | ACE(1) | CRH(1) | DRD3(1) |
Psychotic Disorders | DRD3(5) | SLC6A4(3) | DRD4(3) | HTR2A(3) | DTNBP1(2) | DISC1(2) | DRD2(2) | MAOA(1) |
Obsessive-Compulsive Disorder | SLC6A4(4) | HTR2A(3) | COMT(3) | SLC1A1(2) | DRD4(2) | HTR1B(1) | BDNF(1) | NRCAM(1) |
Panic Disorder | CCK(4) | HTR1A(2) | MAOA(2) | HTR2A(2) | DBI(1) | CCKAR(1) | ADORA2A(1) | PGR(1) |
Cognition Disorders | APOE(3) | BDNF(3) | DRD4(2) | COMT(2) | HMGCR(1) | DTNBP1(1) | SLC6A4(1) | NQO1(1) |
DISEASE CLASS - NERVOUS SYSTEM DISEASES | Â | Â | Â | Â | Â | Â | Â | Â |
Alzheimer Disease | APOE(70) | PSEN1(14) | A2M(10) | CYP46A1(8) | ACE(7) | BCHE(7) | IL1A(7) | BDNF(6) |
Parkinson Disease | PARK2(9) | LRRK2(9) | CYP2D6(7) | MAOB(7) | BDNF(5) | SNCA(5) | PON1(4) | PINK1(4) |
Multiple Sclerosis | HLADRB1(8) | APOE(5) | CTLA4(4) | PTPRC(4) | MBP(3) | HLA-DQB1(3) | IFNG(2) | CRYAB(2) |
Amyotrophic Lateral Sclerosis | SOD1(6) | PON1(2) | PON2(2) | VEGFA(2) | SMN1(1) | MAPT(1) | MT-ND5(1) | PON3(1) |
Brain Ischemia | FGB(5) | PDE4D(3) | NOS3(3) | ACE(2) | PON1(2) | MTHFR(2) | ITGB3(2) | TLR4(1) |
Cerebrovascular Accident | NOS3(5) | APOE(5) | FGB(5) | PON1(4) | SERPINE1(3) | ALOX5AP(3) | ACE(2) | KL(2) |
Carotid Artery Diseases | NOS3(4) | PON1(3) | MTHFR(3) | CCL2(2) | IL6(2) | APOE(2) | CD14(2) | ACE(1) |
Dementia | APOE(4) | MAPT(3) | MT-ND1(1) | PRNP(1) | PSEN1(1) | TNF(1) | CDC2(1) | IGF1R(1) |
DISEASE CLASS - NUTR. AND METABOLIC DISEASES | Â | Â | Â | Â | Â | Â | Â | Â |
Diabetes Mellitus, Type 2 | ACE(25) | PPARG(18) | ADIPOQ(17) | TCF7L2(15) | CAPN10(14) | HNF4A(13) | FABP2(12) | NOS3(10) |
Obesity | ADRB3(17) | LEPR(12) | MC4R(11) | PPARG(11) | UCP2(11) | ADRB2(10) | UCP1(8) | ADIPOQ(8) |
Insulin Resistance | ADIPOQ(11) | FABP2(10) | INSR(7) | IRS1(7) | ENPP1(7) | ADRB3(6) | NOS3(6) | ACE(5) |
Diabetes Mellitus | PPARG(6) | ACE(3) | INS(3) | NOS3(3) | PON1(2) | UBL5(2) | IRS1(2) | TCF7L2(2) |
Hyperlipidemias | APOA5(5) | FABP2(4) | LPL(3) | APOE(3) | ACE(2) | APOA1(2) | PPARA(2) | PPARG(2) |
Hypertriglyceridemia | APOC3(5) | APOA5(4) | LPL(3) | APOE(3) | ADRB2(2) | APOA4(2) | GP1BA(1) | LTA(1) |
Glucose Intolerance | LEPR(3) | ADIPOQ(3) | IGF1(2) | KCNJ11(2) | PTPN1(2) | PPARG(2) | HNF4A(2) | NEUROG3(1) |
Hypercholesterolemia | APOA1(3) | APOB(3) | F12(3) | ACE(2) | LDLR(2) | LPL(2) | PCSK9(2) | ABCG8(2) |
Metabolic Syndrome | APOC3(3) | UBL5(2) | NOS3(2) | ACE(1) | PPARD(1) | NPY5R(1) | ACE2(1) | RGS2(1) |
DISEASE CLASS - EYE DISEASES | Â | Â | Â | Â | Â | Â | Â | Â |
Macular Degeneration | CFH(19) | APOE(4) | PON1(2) | C2(1) | CFB(1) | ABCA1(1) | HTRA1(1) | MELAS(1) |
Diabetic Retinopathy | VEGFA(7) | AKR1B1(4) | PON1(3) | RAGE(3) | AGER(3) | ACE(2) | ITGA2(2) | ICAM1(2) |
Glaucoma | CYP1B1(3) | OPTN(2) | OPA1(2) | OPTC(1) | EDNRA(1) | MYOC(1) | Â | Â |
Ocular Hypertension | OPTN(2) | CYP1B1(1) | OLFM2(1) | OPA1(1) | Â | Â | Â | Â |
Cataract | GALT(1) | AIPL1(1) | IFNGR1(1) | GCNT2(1) | Â | Â | Â | Â |
Retinal Degeneration | NDP(1) | GUCA1A(1) | AIPL1(1) | COL2A1(1) | RHO(1) | GUCA1B(1) | ABCA4(1) | Â |
Myopia | HLADPB1(1) | LUM(1) | COL2A1(1) | NYX(1) | MYOC(1) | Â | Â | Â |