Significant signaling pathway networks mined from pituitary adenoma protein-mapping dataset. Significant signaling pathway networks that are involved in human pituitary adenoma mapping proteins and that function in (A) cancer, cell-to-cell signaling and interaction, small molecule biochemistry (Network 1); (B) post-translational modifications, protein-folding, hematological disease (Network 2); (C) organ morphology, reproductive-system development and function, molecular transport (Network 3); (D) lipid metabolism, molecular transport, smallmolecule biochemistry (Network 4); (E) cell death, hematological disease, cellular development (Network 5); and (F) lipid metabolism, small-molecule biochemistry, carbohydrate metabolism (Network 6). An orange solid edge denotes a direct relationship between two nodes (molecules: proteins; genes). A black unsolid edge denotes an indirect relationship between two nodes (molecules: proteins; genes). A gray node denotes an identified protein in our study . The various shapes of nodes denote the different functions (Additional file 1, Table S1). A duplicated shape means this node contains multiple components. A curved line means intracellular translocation; A curved arrow means extracellular translocation.