Significant signaling pathway networks mined from nitroproteomic dataset. Significant signaling pathway networks that are involved in human pituitary adenoma nitroproteomic data. (A) Network 10 is derived from adenoma nitroproteomic data and function in cancer, cell cycle, reproductive-system disease. A gray node denotes an identified nitroprotein or protein that interact with nitroproteins in our study . (B) Network 11 is derived from control nitroproteomic data and function in gene expression, cellular development, connective tissue development and function. A gray node denotes an identified nitroprotein in our studies [5, 6]. An orange solid edge denotes a direct relationship between two nodes (molecules: proteins; genes). An orange unsolid edge denotes an indirect relationship between two nodes (molecules: proteins; genes). The various shapes of nodes denote the different functions (Additional file 1, Tables S3 and S4). A curved line means intracellular translocation; a curved arrow means extracellular translocation.