Table 2 Signaling Pathway Networks that Involve Human Pituitary Adenoma Differentially Expressed Proteins (DEPs).
From: Signaling pathway networks mined from human pituitary adenoma proteomics data
Networks | Nodes (genes; proteins) in Network | Score | Nodes | Identified Nodes (DEPs) | Top Functions |
|---|---|---|---|---|---|
7 | AKR1B1, Akt, ATP5B, CAPZB, Caspase, CRYM, Cytochrome c, DBI, ERK, F10, FYN, GDI1, GH1, GLO1, GPX4, GSTM2, HSP90B1, HSPB1, HSPB8, Igfbp, IGFBP6, Insulin, Jnk, P38 MAPK, PDGF BB, PI3K, Pka, PLC, PPID, PPP2R2A, PRL, Ras, TGM2, VIM, YWHAQ (includes EG:10971) | 53 | 35 | 22 | Cancer, Endocrine System Development and Function, Organ Morphology |
8 | ACOT2, ACSL1, ADRB3, AKR1B1, ANGPTL4, COL6A2, COX2, COX6B1, Cytochrome c oxidase, DBI, DLK1, DNAJB6, EDN2, ERP29, F2, GCLC, IDH1, IL4R, L-triiodothyronine, LIPE, MMP19, MYCL1, MYLPF, MYOD1, OGN, PPARG, PRDX3, prostaglandin E2, RXRB, SERPINB8, SKI, SLC2A1, TAGLN3, TGFB1, TNF | 22 | 35 | 11 | Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry |
9 | ALB, APOA1, CALB1, CD59, CNTF, CXCR4, CYP2E1, DDIT3, EPO, FGG, G alpha, GH2, GNAO1, GNAS, GPNMB, GPSM1, HBA2, HBB (includes EG:3043), HBD, Histone h3, IFNG, IGFBP2, IGLC1, KLF3, KRT16, Mapk, NFkB, NUPR1, PIK3R1, PIM3, SCGN, SH2B1, SOCS3, TAC1, TPH2 | 19 | 35 | 10 | Hematological System Development and Function, Tissue Morphology, Hematological Disease |