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Table 2 Signaling Pathway Networks that Involve Human Pituitary Adenoma Differentially Expressed Proteins (DEPs).

From: Signaling pathway networks mined from human pituitary adenoma proteomics data

Networks Nodes (genes; proteins) in Network Score Nodes Identified Nodes (DEPs) Top Functions
7 AKR1B1, Akt, ATP5B, CAPZB, Caspase, CRYM, Cytochrome c, DBI, ERK, F10, FYN, GDI1, GH1, GLO1, GPX4, GSTM2, HSP90B1, HSPB1, HSPB8, Igfbp, IGFBP6, Insulin, Jnk, P38 MAPK, PDGF BB, PI3K, Pka, PLC, PPID, PPP2R2A, PRL, Ras, TGM2, VIM, YWHAQ (includes EG:10971) 53 35 22 Cancer, Endocrine System Development and Function, Organ Morphology
8 ACOT2, ACSL1, ADRB3, AKR1B1, ANGPTL4, COL6A2, COX2, COX6B1, Cytochrome c oxidase, DBI, DLK1, DNAJB6, EDN2, ERP29, F2, GCLC, IDH1, IL4R, L-triiodothyronine, LIPE, MMP19, MYCL1, MYLPF, MYOD1, OGN, PPARG, PRDX3, prostaglandin E2, RXRB, SERPINB8, SKI, SLC2A1, TAGLN3, TGFB1, TNF 22 35 11 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry
9 ALB, APOA1, CALB1, CD59, CNTF, CXCR4, CYP2E1, DDIT3, EPO, FGG, G alpha, GH2, GNAO1, GNAS, GPNMB, GPSM1, HBA2, HBB (includes EG:3043), HBD, Histone h3, IFNG, IGFBP2, IGLC1, KLF3, KRT16, Mapk, NFkB, NUPR1, PIK3R1, PIM3, SCGN, SH2B1, SOCS3, TAC1, TPH2 19 35 10 Hematological System Development and Function, Tissue Morphology, Hematological Disease