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Figure 1 | BMC Medical Genomics

Figure 1

From: Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

Figure 1

Schematic diagram for reconstructing the protein-protein association. This diagram shows the basic concept of the reconstruction of protein-protein association. On the protein level, the interactions between proteins from the well-known database and experimental data were extracted. However, this kind of interactions only reflects all possible static connections without stimulus-specific response or temporal changes. Our model includes the gene expression patterns from different time course to infer the dynamic protein-protein associations and networks, suggesting a more significant and realistic method for network reconstruction of the living organism.

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