|
TNF
|
IL-1
|
MyD88-dependent TLR-4
|
MyD88-independent TLR-4
|
Negative regulators
|
|---|
|
TNF
|
IL1α
|
MyD88
|
TLR4
|
A20
|
|
TNFR1
|
IL1β
|
TIRAP
|
TRAM
|
CYLD
|
|
TNFR2
|
IL1R1
|
CD14
|
TRIF
|
FLN29
|
|
TRADD
|
IL1R2
|
PELI2
|
TRAF3
|
IRAK3
|
|
FADD
|
TOLLIP
|
IRAK4
|
TANK
|
NOD2
|
|
GRB2
|
ST2L
|
IRAK1
|
TBK1
|
RIP3
|
|
SOS1
|
PELI1
|
NIK
|
IKKε
|
PTPN11
|
|
CAV1
|
ECSIT
|
BCL10
|
IRF3
|
RNF216
|
|
CASP8
| | | |
SARM
|
|
TRAF2
| | | |
SIGIRR
|
|
TRAF5
| | | |
SOCS1
|
|
TTRAP
| | | |
TMED1
|
|
TRAF6
| | | |
TNIP3
|
|
RIP
| | | |
TRAF4
|
|
MEKK3
| | | |
UBE2N
|
|
TAK1
| | | | |
|
TAB1
| | | | |
|
TAB2
| | | | |
|
IKKα
| | | | |
|
IKKβ
| | | | |
|
IKKγ
| | | | |
- Proteins in the cross-talk analysis are classified into three major pathways, including TNFα, IL-1, TLR-4 (for both MyD88-dependent and MyD88-independent) pathways. The full names of these proteins are listed in the following. BCL10: B-cell CLL/lymphoma 10, NOD2: nucleotide-binding oligomerization domain containing 2, CASP8: caspase 8, apoptosis-related cysteine peptidase, CAV1: caveolin 1, caveolae protein, 22 kDa, CD14: CD14 molecule, IKKα: conserved helix-loop-helix ubiquitous kinase, CYLD: cylindromatosis (turban tumor syndrome), FADD: Fas (TNFRSF6)-associated via death domain, GRB2: growth factor receptor-bound protein 2, IKKβ: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, IKKε: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, IKKγ: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, IL1α: interleukin 1, alpha, IL1β: interleukin 1, beta, IL1R1: interleukin 1 receptor, type I, IL1R2: interleukin 1 receptor, type II, ST2L: interleukin 1 receptor-like 1, IRAK1: interleukin-1 receptor-associated kinase 1, IRAK3: Interleukin-1 receptor-associated kinase 3, IRAK4: interleukin-1 receptor-associated kinase 4, IRF3: interferon regulatory factor 3, NIK: mitogen-activated protein kinase kinase kinase 14, MEKK3: mitogen-activated protein kinase kinase kinase 3, TAK1: Mitogen-activated protein kinase kinase kinase 7, TAB1: mitogen-activated protein kinase kinase kinase 7 interacting protein 1, TAB2: mitogen-activated protein kinase kinase kinase 7 interacting protein 2, MyD88: myeloid differentiation primary response gene (88), PELI1: pellino homolog 1 (Drosophila), PELI2: pellino homolog 2 (Drosophila), PTPN11: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1), RIP: receptor (TNFRSF)-interacting serine-threonine kinase 1, RIP3: receptor-interacting serine-threonine kinase 3, SARM: sterile alpha and TIR motif containing 1, SIGIRR: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, ECSIT: ECSIT homolog (Drosophila), SOCS1: suppressor of cytokine signaling 1, SOS1: Son of sevenless homolog 1 (Drosophila), TANK: TRAF family member-associated NFKB activator, TBK1: TANK-binding kinase 1, TIRAP: toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TLR4: toll-like receptor 4, TMED1: transmembrane emp24 protein transport domain containing 1, TNF: tumor necrosis factor (TNF superfamily, member 2), A20: tumor necrosis factor, alpha-induced protein 3, TNFR1: tumor necrosis factor receptor superfamily, member 1A, TNFR2: tumor necrosis factor receptor superfamily, member 1B, TNIP3: TNFAIP3 interacting protein 3, TOLLIP: toll interacting protein, TRADD: TNFRSF1A-associated via death domain, TRAF2: TNF receptor-associated factor 2, TRAF3: TNF receptor-associated factor 3, TRAF4: TNF receptor-associated factor 4, TRAF5: TNF receptor-associated factor 5, TRAF6: TNF receptor-associated factor 6, FLN29: TRAF-type zinc finger domain containing 1, TRAM: toll-like receptor adaptor molecule 2, RNF216: TRIAD3 protein, TRIF: toll-like receptor adaptor molecule 1, TTRAP: TRAF and TNF receptor associated protein, UBE2N: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
