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Table 1 Human protein candidates and their pathway catalogues in this study.

From: Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

TNF IL-1 MyD88-dependent TLR-4 MyD88-independent TLR-4 Negative regulators
TNF IL1α MyD88 TLR4 A20
TNFR1 IL1β TIRAP TRAM CYLD
TNFR2 IL1R1 CD14 TRIF FLN29
TRADD IL1R2 PELI2 TRAF3 IRAK3
FADD TOLLIP IRAK4 TANK NOD2
GRB2 ST2L IRAK1 TBK1 RIP3
SOS1 PELI1 NIK IKKε PTPN11
CAV1 ECSIT BCL10 IRF3 RNF216
CASP8     SARM
TRAF2     SIGIRR
TRAF5     SOCS1
TTRAP     TMED1
TRAF6     TNIP3
RIP     TRAF4
MEKK3     UBE2N
TAK1     
TAB1     
TAB2     
IKKα     
IKKβ     
IKKγ     
  1. Proteins in the cross-talk analysis are classified into three major pathways, including TNFα, IL-1, TLR-4 (for both MyD88-dependent and MyD88-independent) pathways. The full names of these proteins are listed in the following. BCL10: B-cell CLL/lymphoma 10, NOD2: nucleotide-binding oligomerization domain containing 2, CASP8: caspase 8, apoptosis-related cysteine peptidase, CAV1: caveolin 1, caveolae protein, 22 kDa, CD14: CD14 molecule, IKKα: conserved helix-loop-helix ubiquitous kinase, CYLD: cylindromatosis (turban tumor syndrome), FADD: Fas (TNFRSF6)-associated via death domain, GRB2: growth factor receptor-bound protein 2, IKKβ: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, IKKε: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, IKKγ: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, IL1α: interleukin 1, alpha, IL1β: interleukin 1, beta, IL1R1: interleukin 1 receptor, type I, IL1R2: interleukin 1 receptor, type II, ST2L: interleukin 1 receptor-like 1, IRAK1: interleukin-1 receptor-associated kinase 1, IRAK3: Interleukin-1 receptor-associated kinase 3, IRAK4: interleukin-1 receptor-associated kinase 4, IRF3: interferon regulatory factor 3, NIK: mitogen-activated protein kinase kinase kinase 14, MEKK3: mitogen-activated protein kinase kinase kinase 3, TAK1: Mitogen-activated protein kinase kinase kinase 7, TAB1: mitogen-activated protein kinase kinase kinase 7 interacting protein 1, TAB2: mitogen-activated protein kinase kinase kinase 7 interacting protein 2, MyD88: myeloid differentiation primary response gene (88), PELI1: pellino homolog 1 (Drosophila), PELI2: pellino homolog 2 (Drosophila), PTPN11: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1), RIP: receptor (TNFRSF)-interacting serine-threonine kinase 1, RIP3: receptor-interacting serine-threonine kinase 3, SARM: sterile alpha and TIR motif containing 1, SIGIRR: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, ECSIT: ECSIT homolog (Drosophila), SOCS1: suppressor of cytokine signaling 1, SOS1: Son of sevenless homolog 1 (Drosophila), TANK: TRAF family member-associated NFKB activator, TBK1: TANK-binding kinase 1, TIRAP: toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TLR4: toll-like receptor 4, TMED1: transmembrane emp24 protein transport domain containing 1, TNF: tumor necrosis factor (TNF superfamily, member 2), A20: tumor necrosis factor, alpha-induced protein 3, TNFR1: tumor necrosis factor receptor superfamily, member 1A, TNFR2: tumor necrosis factor receptor superfamily, member 1B, TNIP3: TNFAIP3 interacting protein 3, TOLLIP: toll interacting protein, TRADD: TNFRSF1A-associated via death domain, TRAF2: TNF receptor-associated factor 2, TRAF3: TNF receptor-associated factor 3, TRAF4: TNF receptor-associated factor 4, TRAF5: TNF receptor-associated factor 5, TRAF6: TNF receptor-associated factor 6, FLN29: TRAF-type zinc finger domain containing 1, TRAM: toll-like receptor adaptor molecule 2, RNF216: TRIAD3 protein, TRIF: toll-like receptor adaptor molecule 1, TTRAP: TRAF and TNF receptor associated protein, UBE2N: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)