Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

BMC Medical Genomics

Table 2 Statistics of the TNFα-induced protein-protein association networks of HUVEC.

Duration	Nodes	Edges	Highly connected proteins
0~1HR	56	144	TRAF2	IRAK1	TRAF6	IKKα	IKKβ
1~2HR	56	156	TRAF2	TRAF6	IRAK1	RIP	TNFR1
2~3HR	56	150	IRAK1	TRAF6	TRAF2	IKKα	RIP
3~4HR	55	152	TRAF2	IKKα	TNFR1	IRAK1	TRAF6
4~6HR	56	151	IRAK1	TRAF2	TRAF6	RIP	TNFR1
6~8HR	56	156	TRAF2	TRAF6	RIP	IKKα	IRAK1

Summary of the reconstruction of protein-protein association networks at different time stages. Proteins with maximal protein-protein associations are sorted in this table. These proteins are usually considered as the hubs which will be involved in several biological functions and play important roles in the signaling network.

ISSN: 1755-8794