Skip to main content

Advertisement

Table 2 Statistics of the TNFα-induced protein-protein association networks of HUVEC.

From: Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

Duration Nodes Edges Highly connected proteins
0~1HR 56 144 TRAF2 IRAK1 TRAF6 IKKα IKKβ
1~2HR 56 156 TRAF2 TRAF6 IRAK1 RIP TNFR1
2~3HR 56 150 IRAK1 TRAF6 TRAF2 IKKα RIP
3~4HR 55 152 TRAF2 IKKα TNFR1 IRAK1 TRAF6
4~6HR 56 151 IRAK1 TRAF2 TRAF6 RIP TNFR1
6~8HR 56 156 TRAF2 TRAF6 RIP IKKα IRAK1
  1. Summary of the reconstruction of protein-protein association networks at different time stages. Proteins with maximal protein-protein associations are sorted in this table. These proteins are usually considered as the hubs which will be involved in several biological functions and play important roles in the signaling network.