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Table 4 Proteins with high cross-talk ranking values at different time stages.

From: Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses

Duration Top ranked proteins
0~1HR IRAK1 NIK IKKα TRAF6 IKKβ
1~2HR TRAF6 IRAK1 NIK A20 TRAF2
2~3HR IRAK1 TRAF6 NIK A20 TRAF2
3~4HR IRAK1 NIK TRAF6 A20 IKKγ
4~6HR IRAK1 TRAF6 NIK TRAF2 A20
6~8HR IRAK1 NIK TRAF6 IKKα A20
  1. In contract with Table 2, proteins with maximal CTRVs are listed here. Among these highly ranked proteins, NIK and A20 are considered as two core elements in the signaling network by the analysis of CTRV, but their importance is not exhibited in Table 2. This reveals that our proposed method generates a new insight into the evaluation of cross-talk candidates.