Table 1 Genes specific to the erythroid and megakaryoblastic leukaemias
probeset | gene | SAM results * | Leukaemic samples** | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | d-score | FDR | T1 | T2 | T3 | B1 | B2 | B3 | M | E1 | E2 | E3 | Mk1 | MK2 | Mk3 |
Fibrinogen receptor and related genes | ||||||||||||||||
1417758_at | Itga2b | 10.58 | <0.001 | -2.7 | -1.6 | -2.6 | -2.9 | -2.6 | -2.7 | -1.6 | 3.8 | 0.8 | 1.1 | 3.6 | 3.6 | 3.8 |
1421511_at | Itgb3 | - | >0.01 | -1.0 | -0.7 | -0.7 | -0.8 | -0.7 | -0.9 | -0.6 | 1.6 | -0.7 | -0.7 | -0.6 | 2.9 | 3.1 |
1416066_at | Cd9 | 5.5 | 0.002 | 1.1 | -2.5 | 2.5 | -3.5 | -3.6 | -3.6 | 0.6 | 1.9 | -1.8 | -2.1 | 3.0 | 4.4 | 3.5 |
1456085_x_at | Cd151 | 7.56 | <0.001 | -1.2 | -1.1 | -0.7 | -0.7 | -0.9 | -0.6 | -0.3 | 1.4 | -0.2 | -0.3 | 1.8 | 0.8 | 2.1 |
1420558_at | Selp | 12.03 | <0.001 | -1.0 | -1.2 | -1.9 | -1.6 | -1.5 | -1.7 | -1.1 | -0.9 | -1.7 | -1.6 | 4.3 | 5.7 | 4.1 |
1457782_at | Tln1 | 7.19 | <0.001 | -0.7 | -0.4 | -1.4 | -0.3 | -0.8 | -1.0 | 0.9 | 2.3 | -1.5 | -0.5 | 0.8 | 1.4 | 1.3 |
1424595_at | F11r | 5.58 | 0.002 | -0.9 | -0.8 | -0.9 | -0.8 | -0.6 | -1.0 | -0.6 | 0.2 | -0.6 | -0.6 | 2.0 | 3.1 | 1.5 |
1451097_at | Vasp | 5.24 | <0.001 | -0.8 | -1.3 | 0.1 | 0.3 | -0.3 | 0.3 | 0.7 | 0.0 | -0.6 | -1.0 | 0.8 | 1.2 | 0.7 |
1418261_at | Syk | 16.04 | <0.001 | -2.4 | -2.8 | -2.8 | 2.9 | 2.5 | 2.8 | 1.4 | -1.5 | -2.0 | -3.1 | 1.5 | 1.6 | 1.8 |
1455349_at | Rap1b | 4.63 | <0.001 | -0.7 | -0.8 | -1.1 | -0.6 | -1.2 | -1.0 | -0.2 | 2.1 | -0.3 | 0.9 | 0.7 | 0.9 | 1.4 |
Heme biosynthesis | ||||||||||||||||
1451675_a_at | Alas2 | 8.85 | <0.001 | -3.4 | 0.3 | -0.9 | -2.5 | -3.8 | -3.2 | -1.3 | 4.9 | 4.9 | 4.8 | -2.8 | -0.5 | 3.5 |
1424877_a_at | Alad | 8.91 | <0.001 | -1.2 | -0.4 | 0.0 | -1.3 | -1.6 | -0.7 | -1.6 | 2.2 | 2.2 | 2.0 | 0.4 | -0.9 | 1.2 |
1426475_at | Hmbs | 13.44 | <0.001 | -1.2 | -1.0 | -0.4 | -1.5 | -1.1 | -1.1 | -1.1 | 2.6 | 3.4 | 2.7 | -0.8 | -0.9 | 0.5 |
1423482_at | Uros | - | - | -0.6 | -0.3 | -0.2 | -0.3 | 0.1 | 0.2 | -0.9 | 0.7 | 1.5 | 0.2 | 0.0 | -0.5 | 0.0 |
1417206_at | Urod | 10.87 | <0.001 | 0.0 | -0.4 | -0.3 | -1.2 | -0.9 | -1.0 | -0.3 | 1.8 | 1.6 | 1.4 | -0.6 | -0.5 | 0.3 |
1422493_at | Cpox | 22.18 | <0.001 | -1.6 | -1.2 | -0.2 | -0.5 | -0.8 | -1.0 | -1.5 | 2.7 | 3.1 | 3.2 | -1.0 | -0.7 | -0.4 |
1416618_at | Ppox | 4.58 | 0.004 | -0.5 | -0.1 | -0.3 | 0.1 | -0.2 | -0.4 | 0.0 | 0.7 | 1.4 | 0.6 | -0.6 | -0.4 | -0.4 |
1418699_s_at | Fech | 8.61 | <0.001 | -0.7 | -1.0 | -0.3 | -1.9 | -1.9 | -2.0 | -0.4 | 2.5 | 3.1 | 2.2 | -0.7 | 0.0 | 1.1 |
Erythroid and megakaryoblastic transcription factors | ||||||||||||||||
EMk | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1450333_a_at | Gata2 | 7.4 | 0.01 | -1.9 | -1.6 | -1.9 | -1.7 | -1.8 | -1.9 | -1.1 | -0.6 | 2.2 | 0.6 | 3.4 | 3.4 | 2.8 |
1423603_at | Zfpm1(Fog1) | 5.4 | 0.02 | -1.2 | -1.7 | -1.4 | 0.1 | -0.6 | -0.2 | -3.9 | 2.0 | 2.0 | 2.0 | 1.3 | 0.8 | 0.9 |
1449389_at | Scl/Tal1 | 20.8 | <0.01 | -3.3 | -2.5 | -3.1 | -3.2 | -2.5 | -2.5 | -2.5 | 4.1 | 3.8 | 3.5 | 2.6 | 2.9 | 2.9 |
1454086_a_at | Lmo2 | 4.5 | 0.03 | -5.1 | -3.8 | -4.6 | 0.7 | -1.3 | -0.9 | 0.7 | 2.8 | 3.0 | 2.9 | 1.3 | 2.5 | 1.8 |
1452001_at | Nfe2 | 8.3 | 0.01 | -4.2 | -3.0 | -3.4 | -3.8 | -3.0 | -3.2 | 1.3 | 3.7 | 3.5 | 3.3 | 2.5 | 3.7 | 2.8 |
EMk3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1449232_at | Gata1 | 4.6 | 0.03 | -1.9 | -1.9 | -2.1 | -2.1 | -2.3 | -2.7 | -1.9 | 4.5 | 4.1 | 4.5 | 0.6 | -1.4 | 2.5 |
MkE1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1441584_at | Fli1 | 5.3 | 0.1 | -0.2 | -0.4 | -0.5 | 0.7 | 0.6 | 0.5 | 0.7 | 2.6 | -4.8 | -4.9 | 1.8 | 2.4 | 1.6 |
Erythroid transcription factors | ||||||||||||||||
EMk3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1418600_at | Klf1 | 6.8 | 0.04 | -2.9 | -2.3 | -2.4 | -2.7 | -2.7 | -2.8 | -1.8 | 4.8 | 5.4 | 5.3 | 1.7 | -1.7 | 2.1 |
1419311_at | Trim10 | 8.9 | 0.02 | -2.0 | -1.4 | -2.1 | -2.1 | -2.1 | -2.0 | -1.5 | 5.0 | 4.1 | 3.8 | -1.0 | -0.8 | 2.1 |
Megakaryoblastic transcription factors | ||||||||||||||||
MkE1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1421461_at | Mpl | 16.1 | <0.001 | 0.07 | -1.9 | -1.6 | -2.1 | -2.0 | -2.1 | -2.0 | -1.3 | 1.3 | -1.0 | -1.7 | 4.9 | 4.4 |
MkE1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1440878_at | Runx1 | 4.5 | 0.11 | 0.6 | -1.8 | -1.0 | 0.2 | 0.2 | 0.5 | -0.5 | 0.9 | -0.8 | -0.1 | 0.7 | 0.8 | 0.3 |