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Table 3 Genes specific to the erythroid leukaemias

From: Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus

Probeset Gene SAM results Leukaemic samples*
   d-score p-value FDR T1 T2 T3 B1 B2 B3 M E1 E2 E3 Mk1 MK2 Mk3 E-CE G1E
Correlation with the G1E database
1416193_at Car1 8.2 <0.001 0.02 -3.4 -2.1 -3.2 -3.0 -3.0 -3.2 -2.4 6.0 5.9 1.7 1.4 -2.1 3.0 1.2
1422316_at Gp1ba 12.7 <0.001 0.01 -2.5 -2.1 -1.9 -1.9 -2.0 -2.4 -1.9 4.3 3.3 1.7 0.1 -0.1 3.7 2.9
1422817_at Gp5 7.5 <0.001 0.03 -3.6 -2.3 -3.0 -3.0 -2.9 -2.8 -1.9 4.5 3.6 1.7 2.4 1.6 3.4 3.8
1424968_at 2210023G05Rik 12.3 <0.001 0.01 -2.4 -2.3 -2.1 -2.2 -2.2 -1.9 -1.9 4.4 5.5 5.1 -0.2 -1.1 1.4 1.3
1425677_a_at Ank1 18.2 0.001 0.01 -1.5 -1.3 -1.3 -1.5 -1.1 -0.9 -1.0 3.1 3.6 3.3 -0.5 -1.1 0.1 -0.8
1416464_at Slc4a1 11.6 <0.001 0.02 -2.3 -1.4 -2.0 -2.4 -2.7 -2.0 -1.2 4.7 4.6 1.7 -1.8 0.2 3.2 -2.4
1451675_a_at Alas2 11.0 <0.001 0.02 -3.4 0.3 -0.9 -2.5 -3.8 -3.2 -1.3 4.9 4.9 1.7 -2.8 -0.5 3.5 -1.1
1418699_s_at Fech 8.9 <0.001 0.02 -0.8 -1.0 -0.7 -1.4 -1.7 -1.5 -0.5 2.2 2.5 1.7 -0.2 0.0 1.3 -2.4
Genes potentially implicated in the disease ***
E                    
1417514_at Ssx2ip 13.97 <0.001 0.01 -1.1 -0.8 -1.4 -0.3 -0.3 -0.5 -0.5 2.8 2.7 3.0 -2.4 -1.4 0.3 1.1
1460057_at Gdf3 9.4 <0.001 0.01 -1.3 -1.2 -1.0 -1.3 -0.9 -1.0 2.0 2.2 2.4 2.8 -1.3 -1.3 -0.1 2.9 NS
1419665_a_at Nupr1 8.7 <0.001 0.01 -1.5 -1.5 -1.3 -1.3 -1.3 -1.7 0.3 3.9 2.5 3.3 -0.9 -0.6 0.2 4.0 -
1443969_at Irs2 6.5 <0.001 0.02 0.1 -0.1 -1.5 -0.2 -0.4 0.4 -1.0 1.1 2.1 1.4 -1.2 -0.5 -0.2 1.2
1417165_at Mbd2 17.38 <0.001 0.01 -0.7 -0.1 -0.4 0.0 -0.1 -0.3 -0.6 1.3 1.3 1.3 -0.6 -0.7 -0.2 0.9 -
1449256_a_at Rab11a 10.59 <0.001 0.01 -1.0 -0.3 -1.2 -0.6 -0.6 -0.3 -0.4 1.7 1.7 1.3 -0.3 -0.1 0.2 1.7 -
1417396_at Podxl 6.5 <0.001 0.02 -0.8 -0.9 -1.0 -1.0 -0.9 -0.7 -1.0 1.3 1.6 1.7 1.6 0.2 -0.1 2.4 NS
EMk3                    
1422737_at Ncoa3 4.1 0.003 0.10 -0.3 -1.2 -0.1 -0.5 -0.4 0.3 -0.3 1.5 0.4 0.8 0.0 -0.7 0.6 2.2 NS
1435458_at Pim1 5.4 <0.001 0.06 -1.0 -1.3 -2.0 -0.6 -0.4 -0.4 -0.2 1.5 1.5 1.0 0.1 0.9 0.9 0.6
Genes selected for RT-PCR validation
1449232_at Gata1 4.58 <0.001 0.03 -1.9 -1.9 -2.1 -2.1 -2.3 -2.7 -1.9 4.5 4.1 4.5 0.6 -1.4 2.5 0.4
1425571_at Slamf1 9.9 <0.001 0.02 -1.3 -1.6 -1.7 -1.2 -1.6 -1.5 -2.0 4.1 3.0 1.7 -0.3 -1.2 1.9 4.8 -
1418493_a_at Snca 10.2 <0.001 0.02 -3.3 -0.2 -1.0 -2.5 -3.2 -1.8 -1.5 4.6 4.2 1.7 -1.0 -0.7 2.7 -2.6
1418061_at Ltbp2 15 <0.001 0.01 -0.7 -0.7 -0.7 -0.7 -0.8 -0.7 -0.9 2.2 1.5 1.7 -0.5 -0.8 1.4 2.0 NS
1419069_at Rabgef1 25.0 <0.001 0.01 -0.5 -0.8 -0.4 -0.9 -1.3 -1.2 -0.8 2.2 2.3 2.3 -0.4 -0.4 -0.1 4.8 -
1427357_at Cda 25.0 <0.001 0.01 -1.5 -1.6 -1.6 -1.7 -1.8 -0.6 -1.3 4.3 4.8 4.9 -1.6 -1.7 -0.7 6.0 -
1417152_at Btbd14a 9.5 <0.001 0.02 -0.6 -0.9 -0.9 -0.9 -0.8 -0.9 -0.5 2.3 1.5 1.7 -0.4 -0.4 1.0 2.3 NS
  1. * amplitude of deviation from the mean calculated from the RMA values
  2. ** ratio E-CE: mean of the deviation of E1, E2 and E3/erythroid control value
  3. *** cell cycle/cell growth/development/angiogenesis/DNA repair/transcriptionregulation