Table 3 Genes specific to the erythroid leukaemias
Probeset | Gene | SAM results | Leukaemic samples* | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | d-score | p-value | FDR | T1 | T2 | T3 | B1 | B2 | B3 | M | E1 | E2 | E3 | Mk1 | MK2 | Mk3 | E-CE | G1E |
Correlation with the G1E database | |||||||||||||||||||
1416193_at | Car1 | 8.2 | <0.001 | 0.02 | -3.4 | -2.1 | -3.2 | -3.0 | -3.0 | -3.2 | -2.4 | 6.0 | 5.9 | 1.7 | 1.4 | -2.1 | 3.0 | 1.2 | ↓ |
1422316_at | Gp1ba | 12.7 | <0.001 | 0.01 | -2.5 | -2.1 | -1.9 | -1.9 | -2.0 | -2.4 | -1.9 | 4.3 | 3.3 | 1.7 | 0.1 | -0.1 | 3.7 | 2.9 | ↓ |
1422817_at | Gp5 | 7.5 | <0.001 | 0.03 | -3.6 | -2.3 | -3.0 | -3.0 | -2.9 | -2.8 | -1.9 | 4.5 | 3.6 | 1.7 | 2.4 | 1.6 | 3.4 | 3.8 | ↓ |
1424968_at | 2210023G05Rik | 12.3 | <0.001 | 0.01 | -2.4 | -2.3 | -2.1 | -2.2 | -2.2 | -1.9 | -1.9 | 4.4 | 5.5 | 5.1 | -0.2 | -1.1 | 1.4 | 1.3 | ↓ |
1425677_a_at | Ank1 | 18.2 | 0.001 | 0.01 | -1.5 | -1.3 | -1.3 | -1.5 | -1.1 | -0.9 | -1.0 | 3.1 | 3.6 | 3.3 | -0.5 | -1.1 | 0.1 | -0.8 | ↑ |
1416464_at | Slc4a1 | 11.6 | <0.001 | 0.02 | -2.3 | -1.4 | -2.0 | -2.4 | -2.7 | -2.0 | -1.2 | 4.7 | 4.6 | 1.7 | -1.8 | 0.2 | 3.2 | -2.4 | ↑ |
1451675_a_at | Alas2 | 11.0 | <0.001 | 0.02 | -3.4 | 0.3 | -0.9 | -2.5 | -3.8 | -3.2 | -1.3 | 4.9 | 4.9 | 1.7 | -2.8 | -0.5 | 3.5 | -1.1 | ↑ |
1418699_s_at | Fech | 8.9 | <0.001 | 0.02 | -0.8 | -1.0 | -0.7 | -1.4 | -1.7 | -1.5 | -0.5 | 2.2 | 2.5 | 1.7 | -0.2 | 0.0 | 1.3 | -2.4 | ↑ |
Genes potentially implicated in the disease *** | |||||||||||||||||||
E | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1417514_at | Ssx2ip | 13.97 | <0.001 | 0.01 | -1.1 | -0.8 | -1.4 | -0.3 | -0.3 | -0.5 | -0.5 | 2.8 | 2.7 | 3.0 | -2.4 | -1.4 | 0.3 | 1.1 | ↓ |
1460057_at | Gdf3 | 9.4 | <0.001 | 0.01 | -1.3 | -1.2 | -1.0 | -1.3 | -0.9 | -1.0 | 2.0 | 2.2 | 2.4 | 2.8 | -1.3 | -1.3 | -0.1 | 2.9 | NS |
1419665_a_at | Nupr1 | 8.7 | <0.001 | 0.01 | -1.5 | -1.5 | -1.3 | -1.3 | -1.3 | -1.7 | 0.3 | 3.9 | 2.5 | 3.3 | -0.9 | -0.6 | 0.2 | 4.0 | - |
1443969_at | Irs2 | 6.5 | <0.001 | 0.02 | 0.1 | -0.1 | -1.5 | -0.2 | -0.4 | 0.4 | -1.0 | 1.1 | 2.1 | 1.4 | -1.2 | -0.5 | -0.2 | 1.2 | ↑ |
1417165_at | Mbd2 | 17.38 | <0.001 | 0.01 | -0.7 | -0.1 | -0.4 | 0.0 | -0.1 | -0.3 | -0.6 | 1.3 | 1.3 | 1.3 | -0.6 | -0.7 | -0.2 | 0.9 | - |
1449256_a_at | Rab11a | 10.59 | <0.001 | 0.01 | -1.0 | -0.3 | -1.2 | -0.6 | -0.6 | -0.3 | -0.4 | 1.7 | 1.7 | 1.3 | -0.3 | -0.1 | 0.2 | 1.7 | - |
1417396_at | Podxl | 6.5 | <0.001 | 0.02 | -0.8 | -0.9 | -1.0 | -1.0 | -0.9 | -0.7 | -1.0 | 1.3 | 1.6 | 1.7 | 1.6 | 0.2 | -0.1 | 2.4 | NS |
EMk3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1422737_at | Ncoa3 | 4.1 | 0.003 | 0.10 | -0.3 | -1.2 | -0.1 | -0.5 | -0.4 | 0.3 | -0.3 | 1.5 | 0.4 | 0.8 | 0.0 | -0.7 | 0.6 | 2.2 | NS |
1435458_at | Pim1 | 5.4 | <0.001 | 0.06 | -1.0 | -1.3 | -2.0 | -0.6 | -0.4 | -0.4 | -0.2 | 1.5 | 1.5 | 1.0 | 0.1 | 0.9 | 0.9 | 0.6 | ↑ |
Genes selected for RT-PCR validation | |||||||||||||||||||
1449232_at | Gata1 | 4.58 | <0.001 | 0.03 | -1.9 | -1.9 | -2.1 | -2.1 | -2.3 | -2.7 | -1.9 | 4.5 | 4.1 | 4.5 | 0.6 | -1.4 | 2.5 | 0.4 | ↑ |
1425571_at | Slamf1 | 9.9 | <0.001 | 0.02 | -1.3 | -1.6 | -1.7 | -1.2 | -1.6 | -1.5 | -2.0 | 4.1 | 3.0 | 1.7 | -0.3 | -1.2 | 1.9 | 4.8 | - |
1418493_a_at | Snca | 10.2 | <0.001 | 0.02 | -3.3 | -0.2 | -1.0 | -2.5 | -3.2 | -1.8 | -1.5 | 4.6 | 4.2 | 1.7 | -1.0 | -0.7 | 2.7 | -2.6 | ↑ |
1418061_at | Ltbp2 | 15 | <0.001 | 0.01 | -0.7 | -0.7 | -0.7 | -0.7 | -0.8 | -0.7 | -0.9 | 2.2 | 1.5 | 1.7 | -0.5 | -0.8 | 1.4 | 2.0 | NS |
1419069_at | Rabgef1 | 25.0 | <0.001 | 0.01 | -0.5 | -0.8 | -0.4 | -0.9 | -1.3 | -1.2 | -0.8 | 2.2 | 2.3 | 2.3 | -0.4 | -0.4 | -0.1 | 4.8 | - |
1427357_at | Cda | 25.0 | <0.001 | 0.01 | -1.5 | -1.6 | -1.6 | -1.7 | -1.8 | -0.6 | -1.3 | 4.3 | 4.8 | 4.9 | -1.6 | -1.7 | -0.7 | 6.0 | - |
1417152_at | Btbd14a | 9.5 | <0.001 | 0.02 | -0.6 | -0.9 | -0.9 | -0.9 | -0.8 | -0.9 | -0.5 | 2.3 | 1.5 | 1.7 | -0.4 | -0.4 | 1.0 | 2.3 | NS |