A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease

Table 2 Heritability Estimates of factors in African American and European American pedigrees.

	White			African American
	Factor	Estimate	S.E.	Factor	Estimate	S.E.
Post Aspirin Factors	1W: Collagen/TXM	0.50	0.09	1B: Collagen	0.36	0.14
	2W: Epinephrine	0.61	0.09	2B: High Dose Collagen	0.84	0.13
	3W: High Dose Collagen/TXM	0.47	0.10	3B: Epinephrine	0.46	0.15
	4W: ADP PRP	0.34	0.09	4B: ADP	0.29	0.14
	5W: ADP	0.54	0.09	5B: ADP PRP	0
	6W: Low Dose Collagen	0.40	0.09	6B: Very Low Dose Collagen	0.32	0.15
	7W: Very Low Dose Collagen	0.31	0.09	7B: ADP/Epinephrine	0.33	0.17
	8W: ADP/Epinephrine	0.05	0.09*	8B: TXM	0.51	0.15
Post-adjusted-for-pre Aspirin Factors	1W: High Dose Collagen	0.67	0.11	1B: High Dose Collagen	0.51	0.17
	2W: Epinephrine	0.41	0.10	2B: Epinephrine	0.31	0.13
	3W: Collagen/TXM	0.40	0.10	3B: Collagen	0.43	0.20
	4W: Low Dose Collagen	0.18	0.11*	4B: Low Dose Collagen	0.08	0.12*
	5W: ADP	0.27	0.10	5B: ADP	0.15	0.13*
	6W: Low Dose Collagen	0.18	0.10*	6B: Low Dose Collagen	0.34	0.17
	7W: High Dose ADP	0.21	0.11*	7B: Epinephrine/ADP/Collagen	0.31	0.15
	8W: Epinephrine/Collagen	0.26	0.10	8B: High Dose ADP	0
Pre Aspirin Factors	1W: Collagen	0.19	0.12*	1B: Low Dose Collagen	0.58	0.17
	2W: AA/ADP	0.61	0.10	2B: Collagen	0.19	0.22*
	3W: Low Dose Collagen	0.70	0.10	3B: Epinephrine	0.55	0.19
	4W: Collagen Lag	0.37	0.11	4B: Collagen Lag	0.1	0.13*
	5W: Epinephrine	0.51	0.10	5B: ADP	0.03	0.23*
	6W: ADP/Epinephrine	0.30	0.10	6B: Collagen Lag	0.22	0.15*
	7W: ADP/Epinephrine Lag	0.07	0.10*	7B: PFA	0.12	0.18*
	8W: PFA	0.20	0.11*	8B: AA/ADP/Collagen Lag	0.58	0.17

ISSN: 1755-8794