A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease

Table 3 Summary of multipoint linkage signals in European American pedigrees.

Significance Criteria	Chr	Map Position	Marker	Factor
P < 0.00002	-	-	-
P < 0.00074	3	89.04039	D3S1600	2W(POST):Epinephrine
	4	62.104	D4S405	3W(POST):High Dose Collagen/TXM
	4	67.63	D4S396	3W(POST):High Dose Collagen/TXM
	4	71.03	D4S428	3W(POST):High Dose Collagen/TXM
	5	203.456	D5S469	5W(PP):ADP
	6	174.4557	D6S1581	3W(PP):Collagen/TXM
	11	126.83	D11S4089	2W(POST):Epinephrine
	15	43.142	D15S146	7W(PP):High Dose ADP
	15	52.712	D15S1016	7W(PP):High Dose ADP

POST = Post-ASA Factor, PRE = Pre-ASA Factor, PP = Post-adjusted-for-pre-ASA Factor, Chr = chromosome
Significance criteria as defined by Lander and Kruglyak (1995): suggestive linkage (p-value < 7 × 10^-4) and significant linkage (p-value < 2 × 10^-5).

ISSN: 1755-8794