A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease

Table 4 Summary of multipoint linkage signals in African American pedigrees.

Significance Criteria	Chr	Map position	Marker	Factor
P < 0.00002	5	71.143	D5S628	4B(POST):ADP
	5	80.82	D5S2072	4B(POST):ADP
P < 0.00074	1	160.45	D1S484	2B(PRE):Collagen
	1	216.774	D1S245	4B(POST):ADP
	1	217.215	D1S205	4B(POST):ADP
	2	78.417	D2S2156	5B(POST):ADP PRP
	5	83.18814	D5S1967	4B(POST):ADP
	8	69.341	D8S1737	4B(POST):ADP
	11	154.04129	D11S969	4B(POST):ADP
	17	102.596	D17S940	5B(PP): ADP
	18	21.744	D18S967	7B(POST): ADP/Epinephrine
	19	99.84163	D19S572	4B(PRE):Collagen Lag

POST = Post-ASA Factor, PRE = Pre-ASA Factor, PP = Post-adjusted-for-pre-ASA Factor, Chr = chromosome
Significance criteria as defined by Lander and Kruglyak (1995): suggestive linkage (p-value < 7 × 10^-4) and significant linkage (p-value < 2 × 10^-5).

ISSN: 1755-8794