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Figure 3 | BMC Medical Genomics

Figure 3

From: A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

Figure 3

Acquired resistance to AKT inhibition is associated with increased RAS signature. (A) generation of a cell line with acquired resistance to MK-2206 by culturing in increasing drug concentrations over 7 months. (B) Cells cultured in vehicle for 7 months remain sensitive to AKT inhibition. Cells with acquired resistance to MK-2206 show decreased pAKT (C) and increased pERK (D).

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BMC Medical Genomics

ISSN: 1755-8794

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