Figure 3From: A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors Acquired resistance to AKT inhibition is associated with increased RAS signature. (A) generation of a cell line with acquired resistance to MK-2206 by culturing in increasing drug concentrations over 7 months. (B) Cells cultured in vehicle for 7 months remain sensitive to AKT inhibition. Cells with acquired resistance to MK-2206 show decreased pAKT (C) and increased pERK (D).Back to article page