Figure 1
From: Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome
Quantitative mRNA expression in ATRX patients. A. qRT-PCR analysis of the OPHN-1, GRAF1/OPHN-1-L, G0/G1 and HAIK1 transcript levels in ATRX patients (n = 3, ATRX-1, ATRX-2, ATRX-3) and in normal controls (n = 8). Results are expressed as percentage of control average. Each bar represents the mean ± SEM. Statistical significance was determined by Student t test and indicated by asterisks: * p < 0.05; ** p < 0.01. B. qRT-PCR analysis showing a reduction of the GRAF1/OPHN-1-L transcript levels in the immortalized cell lines belonging to two ATRX patients, ATRX-1, ATRX-2. Results are expressed as percentage of control average (n = 4 immortalized cell lines from normal subjects). Each column is the average of three determination ± SD: * p < 0.01.