Skip to main content

Advertisement

Table 4 Over-represented Panther biological processes in modules correlated to a metabolic trait in subcutaneous (SAT) and visceral adipose tissue (VAT)

From: Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study

  SAT Module 4 SAT Module 8 VAT Module 9
  No. of genes in module P-value No. of genes in module P-value No. of genes in module P-value
Total 308   87   103  
Signal transduction 67 2.8 × 10-4 NA NS NA NS
- Intracellular signalling cascade 26 2.0 × 10-3 NA NS NA NS
Immunity and defense 43 3.5 × 10-9 31 4.1 × 10-17 21 8.2 × 10-7
- T-cell-mediated immunity 13 9.2 × 10-5 7 6.4 × 10-4 NA NS
- MHCII-mediated immunity NA NS 5 2.5 × 10-5 NA NS
- Macrophage-mediated immunity NA NS 7 7.5 × 10-5 5 3.3 × 10-2
- Endocytosis NA NS 7 6.2 × 10-3 NA NS
- B-cell and antibody-mediated immunity 7 2.4 × 10-2 4 4.9 × 10-2 NA NS
- Complement mediated immunity NA NS 4 2.4 × 10-3 NA NS
Transport 41 2.8 × 10-7 NA NS 16 1.2 × 10-3
- Ion transport 23 1.8 × 10-4 NA NS NA NS
Cell adhesion 20 1.6 × 10-3 NA NS 11 9.2 × 10-4
Lipid, fatty acid and steroid metabolism 21 9.7 × 10-3 NA NS NA NS
Carbohydrate metabolism 19 2.5 × 10-3 NA NS NA NS
Other 89 NA 37 NA 44 NA
Unclassified 76 NA 19 NA 24 NA
  1. SAT modules 4 and 8 correlate to HDL, and VAT module 9 correlates to glucose. The modules SAT 12, SAT 39, VAT 40 do not contain enough genes to perform a reliable pathway analysis. The modules correlated to gender in both tissues consist solely of Y-chromosomal genes and are not included in the table.
  2. Only biological functions that are over-represented in a module after Bonferroni correction are shown. For each over-represented biological function the number of genes in the module that belong to this biological function, and the corresponding Bonferroni corrected p-value for over-representation are shown. The number of genes that are part of a class which is not over- or under-represented, and the number of genes that could not be classified by PANTHER are also shown for each module ("other" and "unclassified" respectively). NA, not applicable; NS, not significant.