TY - JOUR AU - Liu, Qian AU - Zhang, Hao AU - Smeester, Lisa AU - Zou, Fei AU - Kesic, Matt AU - Jaspers, Ilona AU - Pi, Jingbo AU - Fry, Rebecca C. PY - 2010 DA - 2010/08/13 TI - The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel JO - BMC Medical Genomics SP - 37 VL - 3 IS - 1 AB - Drinking water contaminated with inorganic arsenic is associated with increased risk for different types of cancer. Paradoxically, arsenic trioxide can also be used to induce remission in patients with acute promyelocytic leukemia (APL) with a success rate of approximately 80%. A comprehensive study examining the mechanisms and potential signaling pathways contributing to the anti-tumor properties of arsenic trioxide has not been carried out. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-3-37 DO - 10.1186/1755-8794-3-37 ID - Liu2010 ER -