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Table 1 Significantly differentially regulated pathways.

From: Analyzing the regulation of metabolic pathways in human breast cancer

Rank Pathway Differentially regulated Number of reactions Down-regulated in unfavorable Up-regulated in unfavorable P-value
1 Histidine metabolism 6 14 3 3 1.15E-05
2 Alanine and aspartate metabolism 8 19 2 6 1.56E-05
3 Valine, leucine and isoleucine degradation 13 36 10 3 3.74E-05
4 Pyrimidine metabolism 37 75 3 34 2.25E-04
5 Fatty acid metabolism 14 36 9 5 2.48E-04
6 Biosynthesis of Steroids 10 41 2 8 3.12E-04
7 Methionine metaboplism 4 12 2 2 7.36E-04
8 Purine metabolism 17 91 3 14 1.21E-03
9 Glycine, Serine and Threonine metabolism 12 31 4 8 1.28E-03
10 Propanoate metabolism 4 18 3 1 2.12E-03
11 Lysine Biosynthesis 6 6 5 1 2.33E-03
12 Aminoacyl-tRNA biosynthesis 5 20 1 4 2.83E-03
13 Glycolysis/Gluconeogenesis 17 32 1 16 3.85E-03
14 Bile acid biosynthesis 10 28 4 6 5.26E-03
15 Pentose phosphate pathway 5 20 1 4 8.84E-03
16 Inositol phosphate metabolism 8 25 1 7 9.75E-03
17 Pyruvate metabolism 6 27 2 4 1.20E-02
18 Fructose and mannose metabolism 11 23 1 10 1.55E-02
19 Galactose metabolism 8 24 4 4 2.00E-02
  1. Pathways with significant regulation patterns and more than three differentially regulated reactions (as defined by KEGG), bold: pathways which had also significant patterns in the second analyzed dataset.