Table 1 Significantly differentially regulated pathways.
From: Analyzing the regulation of metabolic pathways in human breast cancer
Rank | Pathway | Differentially regulated | Number of reactions | Down-regulated in unfavorable | Up-regulated in unfavorable | P-value |
|---|---|---|---|---|---|---|
1 | Histidine metabolism | 6 | 14 | 3 | 3 | 1.15E-05 |
2 | Alanine and aspartate metabolism | 8 | 19 | 2 | 6 | 1.56E-05 |
3 | Valine, leucine and isoleucine degradation | 13 | 36 | 10 | 3 | 3.74E-05 |
4 | Pyrimidine metabolism | 37 | 75 | 3 | 34 | 2.25E-04 |
5 | Fatty acid metabolism | 14 | 36 | 9 | 5 | 2.48E-04 |
6 | Biosynthesis of Steroids | 10 | 41 | 2 | 8 | 3.12E-04 |
7 | Methionine metaboplism | 4 | 12 | 2 | 2 | 7.36E-04 |
8 | Purine metabolism | 17 | 91 | 3 | 14 | 1.21E-03 |
9 | Glycine, Serine and Threonine metabolism | 12 | 31 | 4 | 8 | 1.28E-03 |
10 | Propanoate metabolism | 4 | 18 | 3 | 1 | 2.12E-03 |
11 | Lysine Biosynthesis | 6 | 6 | 5 | 1 | 2.33E-03 |
12 | Aminoacyl-tRNA biosynthesis | 5 | 20 | 1 | 4 | 2.83E-03 |
13 | Glycolysis/Gluconeogenesis | 17 | 32 | 1 | 16 | 3.85E-03 |
14 | Bile acid biosynthesis | 10 | 28 | 4 | 6 | 5.26E-03 |
15 | Pentose phosphate pathway | 5 | 20 | 1 | 4 | 8.84E-03 |
16 | Inositol phosphate metabolism | 8 | 25 | 1 | 7 | 9.75E-03 |
17 | Pyruvate metabolism | 6 | 27 | 2 | 4 | 1.20E-02 |
18 | Fructose and mannose metabolism | 11 | 23 | 1 | 10 | 1.55E-02 |
19 | Galactose metabolism | 8 | 24 | 4 | 4 | 2.00E-02 |