EPC number, mobilization and morphology in DS. A) EPCs number in euploids and DS determided as Dil-Ac-LDL/Lectin double positive cells (*P < .0001). B) EPC size measured by confocal microscopy and ImageJ (*P < .0001). C) Morphological characterization by TEM of EPCs isolated from euploids and DS. Scale bar: 5 ìm. D) SDF-1α plasma levels in DS and euploids (*P < .0001). E) Relative expression levels of CXCL12 and CXCR4 genes in euploids and DS measured by qRT-PCR (*P < 0.05).