Table 1 Differential expression of angiogenesis-related genes in DS vs C endothelial progenitors
From: Impairment of circulating endothelial progenitors in Down syndrome
Gene name | Gene symbol | RefSeq | Fold change | Function |
|---|---|---|---|---|
Chemokine (C-X-C motif) ligand 10 | CXCL10 | NM_001565 | 6.7 I | Antiangiogenic chemokine |
Interferon stimulated gene 20 | ISG20 | NM_002201 | 4.4 I | Angiogenesis inhibitor |
SAM domain- and HD domain-containing protein 1 | SAMHD1 | NM_015474 | 3.0 I | Interferon-γ stimulated; angiogenesis inhibitor |
Caspase 8 | CASP8 | NM_001228 | 3.5 D | Adhesion and homing of EPC |
Chemokine (C-X-C motif) ligand 12 | CXCL12 | NM_199168 | 10.2 D; 5.7 D | Mobilization and recruitment of EPCs |
Chemokine (C-X-C motif) receptor 4 | CXCR4 | NM_001008540 | 3.0 D | Endothelial cells migration and homing |
Chemokine (C-X-C motif) receptor 7 | CXCR7 | NM_020311 | 4.3 D | Endothelial cells migration and homing |
Endothelin 1 | EDN1 | NM_001955 | 13.6 D; 3.5 D | Promotes migration and proliferation of endothelial cells |
Endothelin receptor type B | EDNRB | NM_000115 | 2.8 D | Migration, proliferation of endothelial cells |
Vascular endothelial growth factor A | VEGFA | NM_001025367 | 3.6 D | Angioproliferative |
Stanniocalcin 1 | STC1 | NM_003155 | 56.0 D | VEGF-mediated angiogenic response |