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Table 1 Differential expression of angiogenesis-related genes in DS vs C endothelial progenitors

From: Impairment of circulating endothelial progenitors in Down syndrome

Gene name Gene symbol RefSeq Fold change Function
Chemokine (C-X-C motif) ligand 10 CXCL10 NM_001565 6.7 I Antiangiogenic chemokine
Interferon stimulated gene 20 ISG20 NM_002201 4.4 I Angiogenesis inhibitor
SAM domain- and HD domain-containing protein 1 SAMHD1 NM_015474 3.0 I Interferon-γ stimulated; angiogenesis inhibitor
Caspase 8 CASP8 NM_001228 3.5 D Adhesion and homing of EPC
Chemokine (C-X-C motif) ligand 12 CXCL12 NM_199168 10.2 D; 5.7 D Mobilization and recruitment of EPCs
Chemokine (C-X-C motif) receptor 4 CXCR4 NM_001008540 3.0 D Endothelial cells migration and homing
Chemokine (C-X-C motif) receptor 7 CXCR7 NM_020311 4.3 D Endothelial cells migration and homing
Endothelin 1 EDN1 NM_001955 13.6 D; 3.5 D Promotes migration and proliferation of endothelial cells
Endothelin receptor type B EDNRB NM_000115 2.8 D Migration, proliferation of endothelial cells
Vascular endothelial growth factor A VEGFA NM_001025367 3.6 D Angioproliferative
Stanniocalcin 1 STC1 NM_003155 56.0 D VEGF-mediated angiogenic response