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Table 1 Distribution of studied variables among MDS and control mothers

From: Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks

Variable

MDS (n = 29)

Controls (n = 32)

MTHFR 677C>T

CC: 5

CC: 11

 

CT: 19

CT: 17

 

TT: 5

TT: 4

MTHFR 1298 A>C

AA: 14

AA: 13

 

AC: 15

AC: 19

 

CC: 0

CC: 0

MTRR 66 A>G

AA: 9

AA: 12

 

AG: 14

AG: 14

 

GG: 6

GG: 6

MTR 2756 A>G

AA: 20

AA: 24

 

AG: 9

AG: 6

 

GG: 0

GG: 2

RFC1 80 G>A

GG: 12

GG: 10

 

GA: 16

GA: 12

 

AA: 1

AA: 10

TYMS 28bp repeat

2R/2R: 5

2R/2R: 6

 

2R/3R: 19

2R/3R: 14

 

3R/3R: 5

3R/3R: 12

TYMS 1494 6bp deletion

6bp +/+: 5

6pb +/+: 8

 

6bp +/-: 21

6bp +/-: 19

 

6bp -/-: 3

6bp -/-: 5

BNMN‰ (mean ± SD)

16.5 ± 7.6

9.3 ± 3.1