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Table 5 Characteristics of genes with novel association to castration-recurrence in vivo

From: LNCaP Atlas: Gene expression associated with in vivoprogression to castration-recurrent prostate cancer

    

Associated with

    

Associated with

Gene*

S or PM†

Reg. by A‡

Spec. to P§

CaPII

GG¶

Prog.**

Mets††

CR‡‡

Gene

S or PM

Reg. by A

Spec. to P

CaP

GG

Prog.

Mets

CR

ABHD2

PM

Y↑

-

Y↑

-

-

-

-

NKX3-1

-

Y↑

Y

-

-

-

Y

-

ACY1

-

-

-

-

-

-

-

-

ODC1

-

Y↑

-

Y↑

-

Y↓

-

Y↑

AQP3

PM

-

-

-

-

-

-

-

OPRK1

PM

-

-

-

-

-

-

-

ATP5G2

-

-

-

-

-

-

-

-

OR51E2

PM

-

-

Y↑

-

-

-

-

B2M

S&PM

Y↑

-

-

-

Y↑

-

Y↓

P4HA1

-

Y

-

-

-

-

-

-

BNIP3

-

-

-

Y↓

-

-

-

-

PCGEM1

-

Y↑

Y

Y↑

-

Y↑

-

-

BTG1

-

Y↓

-

-

-

-

-

-

PCOTH

-

-

Y

Y↑

-

Y↑

-

-

C17orf45

-

-

-

-

-

-

-

-

PGK1

-

Y↑

-

Y↓

Y↑

-

Y ↑↓§§

-

C19orf48

S

Y↑

-

-

-

-

-

-

PIK3CD

-

-

-

-

-

-

Y↑

Y↑

C1orf80

-

-

-

-

Y↑

-

-

-

PJA2

-

-

-

-

-

-

-

-

CAMK2N1

-

Y↓

-

-

Y↑

Y↑

-

-

PLCB4

PM

-

-

-

-

-

-

-

CCNH

-

-

-

-

-

-

-

-

PPP2CB

-

-

-

Y↓

-

-

-

-

CCT2

-

-

-

-

-

-

-

-

PPP2R1A

-

-

-

-

-

-

-

-

CD151

PM

-

-

-

-

Y↑

Y↑

-

PSMA7

-

-

-

Y↓

-

-

-

-

COMT

-

-

-

-

-

Y↓

-

-

PTGFR

PM

-

-

-

-

-

-

-

CUEDC2

-

-

-

-

-

-

-

-

QKI

-

-

-

-

-

-

-

-

CXCR7

PM

Y↓

-

-

-

-

Y↑

Y↑

RAMP1

PM

-

Y

Y↑

-

-

-

-

DHRS7

PM

-

-

-

-

-

Y↓

-

RNF208

-

-

-

-

-

-

-

-

EEF1A2

-

Y↑

-

Y↑

-

-

-

-

RPL11

-

-

-

-

-

-

Y↓

-

EEF2

-

-

-

-

-

-

-

-

RPL28

-

-

-

-

-

-

-

-

ELOVL5

PM

Y

Y

Y↓

-

-

-

-

RPS11

-

-

-

-

-

-

Y↓

-

ENDOD1

S

Y↑

-

-

-

-

-

-

RPS18

-

-

-

Y↑

-

-

-

-

ENO2

PM

-

-

-

-

-

-

-

RPS3

-

-

-

-

-

-

-

-

ENSG00000210082

-

-

-

-

-

-

-

-

S100A10

PM

-

-

-

-

-

-

-

ENSG00000211459

-

-

-

-

-

-

-

-

SBDS

-

-

-

-

-

Y↑

-

-

FGFRL1

PM

-

-

-

-

-

-

-

SELENBP1

-

Y↓

-

Y↓

-

-

-

-

FKBP10

-

-

-

-

-

-

-

-

SERINC5

-

-

-

-

-

-

-

-

GALNT3

-

-

-

Y↑

-

Y↓

-

-

SF3A2

-

-

-

-

-

-

Y↑

-

GAS5

-

-

-

-

-

-

-

-

SFRS2B

-

-

-

-

-

-

-

-

GLO1

-

-

-

Y↑

Y↑

Y↑

-

-

SH3BP5L

-

-

-

-

-

-

-

-

GNB2L1

PM

-

-

-

-

-

Y↑

-

SLC25A4

-

-

-

Y↑

-

-

-

-

GRB10

PM

-

-

-

-

-

-

-

SLC25A6

-

-

-

Y↑

-

-

-

-

H2AFJ

-

-

-

-

-

-

-

-

SNX3

-

-

-

-

Y↑

-

-

-

HES6

-

-

-

-

-

-

Y↑

Y↑

SPIRE1

-

-

-

-

-

-

-

-

HLA-B

PM

-

-

-

-

-

-

-

SPON2

S

-

Y

Y↑

-

-

-

-

HMGB2

-

-

-

-

-

-

-

Y↑

STEAP1

PM

-

Y

Y↑

-

-

-

-

HN1

-

-

-

-

-

-

Y↑

-

SYNC1

-

-

-

-

-

-

-

-

HSD17B4

-

Y↑

-

Y↑

-

-

-

-

TFPI

S

-

-

-

-

-

-

-

LOC644844

-

-

-

-

-

-

-

-

TK1

-

-

-

-

-

-

Y↑

-

MAOA

-

Y

-

-

Y↑

-

-

-

TKT

-

-

-

-

-

-

-

-

MARCKSL1

PM

-

-

Y↑

-

-

-

-

TMEM30A

S&PM

-

-

-

-

Y↑

-

-

MDK

S&PM

Y↓

-

Y↑

-

-

-

Y↑

TMEM66

S&PM

Y↑

-

-

-

-

-

-

MT-CO3

-

-

-

-

-

-

-

-

TPD52

-

Y↑

Y

Y↑

-

Y↑

Y↓

-

MT-ND3

-

-

-

-

-

-

-

-

TRPM8

PM

Y↑

-

Y↑

-

-

-

Y↓

NAAA

-

-

-

-

-

-

-

Y↑

UTX

-

-

-

-

-

-

-

-

NAT14

PM

-

-

-

-

-

-

-

VPS13B

PM

-

-

-

-

-

Y↑

-

NELF

PM

-

-

-

-

-

-

-

WDR45L

-

-

-

-

-

-

-

-

NGFRAP1

-

-

-

Y↓

-

-

-

-

YWHAQ

-

-

-

-

-

-

-

-

  1. * Human Genome Nomenclature Committee (HGNC)-approved gene names were used when possible. Non-HGNC-approved gene names were not italicized.
  2. † S or PM, gene product is thought to be secreted (S) or localize to the plasma membrane (PM)
  3. ‡ Reg. by A, gene expression changes in response to androgen in prostate cells
  4. § Spec. to P, gene expression is specific to- or enriched in- prostate tissue compared to other tissues
  5. II CaP, gene is differentially expressed in prostate cancer compared to normal, benign prostatic hyperplasia, or prostatic intraepithelial neoplasia
  6. ¶ GG, gene is differentially expressed in higher Gleason grade tissue versus lower Gleason grade tissue
  7. ** Prog., gene expression correlates with late-stage prostate cancer or is a risk factor that predicts progression
  8. †† Mets, gene expression is associated with prostate cancer metastasis in human samples or in vivo models
  9. ‡‡ CR, gene is associated with castration-recurrent prostate cancer in human tissue or in vivo models, but exhibits an opposite trend of this report
  10. §§ Y, yes; ↑, high gene expression; ↓, low gene expression
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BMC Medical Genomics

ISSN: 1755-8794

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