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Table 5 Characteristics of genes with novel association to castration-recurrence in vivo

From: LNCaP Atlas: Gene expression associated with in vivoprogression to castration-recurrent prostate cancer

     Associated with      Associated with
Gene* S or PM† Reg. by A‡ Spec. to P§ CaPII GG¶ Prog.** Mets†† CR‡‡ Gene S or PM Reg. by A Spec. to P CaP GG Prog. Mets CR
ABHD2 PM Y↑ - Y↑ - - - - NKX3-1 - Y↑ Y - - - Y -
ACY1 - - - - - - - - ODC1 - Y↑ - Y↑ - Y↓ - Y↑
AQP3 PM - - - - - - - OPRK1 PM - - - - - - -
ATP5G2 - - - - - - - - OR51E2 PM - - Y↑ - - - -
B2M S&PM Y↑ - - - Y↑ - Y↓ P4HA1 - Y - - - - - -
BNIP3 - - - Y↓ - - - - PCGEM1 - Y↑ Y Y↑ - Y↑ - -
BTG1 - Y↓ - - - - - - PCOTH - - Y Y↑ - Y↑ - -
C17orf45 - - - - - - - - PGK1 - Y↑ - Y↓ Y↑ - Y ↑↓§§ -
C19orf48 S Y↑ - - - - - - PIK3CD - - - - - - Y↑ Y↑
C1orf80 - - - - Y↑ - - - PJA2 - - - - - - - -
CAMK2N1 - Y↓ - - Y↑ Y↑ - - PLCB4 PM - - - - - - -
CCNH - - - - - - - - PPP2CB - - - Y↓ - - - -
CCT2 - - - - - - - - PPP2R1A - - - - - - - -
CD151 PM - - - - Y↑ Y↑ - PSMA7 - - - Y↓ - - - -
COMT - - - - - Y↓ - - PTGFR PM - - - - - - -
CUEDC2 - - - - - - - - QKI - - - - - - - -
CXCR7 PM Y↓ - - - - Y↑ Y↑ RAMP1 PM - Y Y↑ - - - -
DHRS7 PM - - - - - Y↓ - RNF208 - - - - - - - -
EEF1A2 - Y↑ - Y↑ - - - - RPL11 - - - - - - Y↓ -
EEF2 - - - - - - - - RPL28 - - - - - - - -
ELOVL5 PM Y Y Y↓ - - - - RPS11 - - - - - - Y↓ -
ENDOD1 S Y↑ - - - - - - RPS18 - - - Y↑ - - - -
ENO2 PM - - - - - - - RPS3 - - - - - - - -
ENSG00000210082 - - - - - - - - S100A10 PM - - - - - - -
ENSG00000211459 - - - - - - - - SBDS - - - - - Y↑ - -
FGFRL1 PM - - - - - - - SELENBP1 - Y↓ - Y↓ - - - -
FKBP10 - - - - - - - - SERINC5 - - - - - - - -
GALNT3 - - - Y↑ - Y↓ - - SF3A2 - - - - - - Y↑ -
GAS5 - - - - - - - - SFRS2B - - - - - - - -
GLO1 - - - Y↑ Y↑ Y↑ - - SH3BP5L - - - - - - - -
GNB2L1 PM - - - - - Y↑ - SLC25A4 - - - Y↑ - - - -
GRB10 PM - - - - - - - SLC25A6 - - - Y↑ - - - -
H2AFJ - - - - - - - - SNX3 - - - - Y↑ - - -
HES6 - - - - - - Y↑ Y↑ SPIRE1 - - - - - - - -
HLA-B PM - - - - - - - SPON2 S - Y Y↑ - - - -
HMGB2 - - - - - - - Y↑ STEAP1 PM - Y Y↑ - - - -
HN1 - - - - - - Y↑ - SYNC1 - - - - - - - -
HSD17B4 - Y↑ - Y↑ - - - - TFPI S - - - - - - -
LOC644844 - - - - - - - - TK1 - - - - - - Y↑ -
MAOA - Y - - Y↑ - - - TKT - - - - - - - -
MARCKSL1 PM - - Y↑ - - - - TMEM30A S&PM - - - - Y↑ - -
MDK S&PM Y↓ - Y↑ - - - Y↑ TMEM66 S&PM Y↑ - - - - - -
MT-CO3 - - - - - - - - TPD52 - Y↑ Y Y↑ - Y↑ Y↓ -
MT-ND3 - - - - - - - - TRPM8 PM Y↑ - Y↑ - - - Y↓
NAAA - - - - - - - Y↑ UTX - - - - - - - -
NAT14 PM - - - - - - - VPS13B PM - - - - - Y↑ -
NELF PM - - - - - - - WDR45L - - - - - - - -
NGFRAP1 - - - Y↓ - - - - YWHAQ - - - - - - - -
  1. * Human Genome Nomenclature Committee (HGNC)-approved gene names were used when possible. Non-HGNC-approved gene names were not italicized.
  2. † S or PM, gene product is thought to be secreted (S) or localize to the plasma membrane (PM)
  3. ‡ Reg. by A, gene expression changes in response to androgen in prostate cells
  4. § Spec. to P, gene expression is specific to- or enriched in- prostate tissue compared to other tissues
  5. II CaP, gene is differentially expressed in prostate cancer compared to normal, benign prostatic hyperplasia, or prostatic intraepithelial neoplasia
  6. ¶ GG, gene is differentially expressed in higher Gleason grade tissue versus lower Gleason grade tissue
  7. ** Prog., gene expression correlates with late-stage prostate cancer or is a risk factor that predicts progression
  8. †† Mets, gene expression is associated with prostate cancer metastasis in human samples or in vivo models
  9. ‡‡ CR, gene is associated with castration-recurrent prostate cancer in human tissue or in vivo models, but exhibits an opposite trend of this report
  10. §§ Y, yes; ↑, high gene expression; ↓, low gene expression