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Table 1 Molecular signature of 17AAG response in breast cancer

From: Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

20 Genes up-regulated following 17AAG treatment
Gene name Description FDR Fold Change
CHORDC1 Cysteine and histidine-rich domain (CHORD)-containing 1 (CHORDC1) 0.011 3.9
DEDD2 Death effector domain containing 2 (DEDD2) 0.011 2.2
HSPA8 Heat shock 70kDa protein 8 (HSPA8) transcript variant 1 0.011 4.6
NUDT9 Nudix (nucleoside diphosphate linked moiety X)-type motif 9 (NUDT9). transcript variant 1 0.011 2.4
PRDM11 PR domain containing 11 (PRDM11) 0.011 2.8
UBE2C Ubiquitin-conjugating enzyme E2C (UBE2C) 0.011 2.4
ZFP95 Zinc finger protein 95 homolog (mouse) (ZFP95). transcript variant 1 0.02 1.5
ZNF587 Zinc finger protein 587 (ZNF587) transcript variant 1 0.025 2.8
RGS2 Regulator of G-protein signalling 2. 24kDa (RGS2) 0.03 4.8
CR2 CR2/CD21/C3d/Epstein-Barr virus receptor mRNA. complete cds. [M26004] 0.034 2.5
DNAJA1 DnaJ (Hsp40) homolog. subfamily A. member 1 (DNAJA1) 0.034 3.3
HSPA1L Heat shock 70kDa protein 1-like (HSPA1L) 0.034 3.1
MICB MHC class I polypeptide-related sequence B (MICB) 0.034 1.4
RACGAP1 Rac GTPase activating protein 1 (RACGAP1) 0.034 2.1
ZNF473 Zinc finger protein 473 (ZNF473). transcript variant 1 0.034 1.7
DNAJB12 DnaJ (Hsp40) homolog. subfamily B. member 12 (DNAJB12). transcript variant 1 0.035 1.6
HSP90AA1 Heat shock protein 90kDa alpha (cytosolic). class A member 1 (HSP90AA1) transcript variant 2 0.045 5.3
PPARBP PPAR binding protein. mRNA (cDNA clone IMAGE:4822636). complete cds. [BC060758] 0.045 1.7
CCDC12 Coiled-coil domain containing 12 (CCDC12) 0.046 1.8
HSPA4L Heat shock 70kDa protein 4-like (HSPA4L) 0.046 3.6
15 Genes down-regulated following 17AAG treatment
Gene name Description FDR Fold Change
PLK3 Polo-like kinase 3 (Drosophila) (PLK3) 0.025 5.8
TMEM129 Transmembrane protein 129 (TMEM129) 0.027 2.2
IER3 Immediate early response 3 (IER3). transcript variant short 0.032 8.7
CCND1 Cyclin D1 (CCND1) 0.034 5.5
JUNB Jun B proto-oncogene (JUNB) 0.034 5
TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae) (TSEN2) 0.034 2.8
CCDC85B Coiled-coil domain containing 85B (CCDC85B) 0.035 2.3
WDR4 WD repeat domain 4 (WDR4). transcript variant 2 0.035 2.5
RFC4 Replication factor C (activator 1) 4. 37kDa (RFC4). transcript variant 1 0.044 2.2
PYCRL Pyrroline-5-carboxylate reductase-like (PYCRL) 0.045 2.9
SHMT2 Serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2) 0.045 1.7
C6orf203 Chromosome 6 open reading frame 203 (C6orf203) 0.046 2.2
MAN1B1 Mannosidase. alpha. class 1B. member 1 (MAN1B1) 0.046 2.2
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor. alpha (NFKBIA) 0.047 4.2
SFT2D3 SFT2 domain containing 3 (SFT2D3) 0.047 1.9