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Table 1 Molecular signature of 17AAG response in breast cancer

From: Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

20 Genes up-regulated following 17AAG treatment

Gene name

Description

FDR

Fold Change

CHORDC1

Cysteine and histidine-rich domain (CHORD)-containing 1 (CHORDC1)

0.011

3.9

DEDD2

Death effector domain containing 2 (DEDD2)

0.011

2.2

HSPA8

Heat shock 70kDa protein 8 (HSPA8) transcript variant 1

0.011

4.6

NUDT9

Nudix (nucleoside diphosphate linked moiety X)-type motif 9 (NUDT9). transcript variant 1

0.011

2.4

PRDM11

PR domain containing 11 (PRDM11)

0.011

2.8

UBE2C

Ubiquitin-conjugating enzyme E2C (UBE2C)

0.011

2.4

ZFP95

Zinc finger protein 95 homolog (mouse) (ZFP95). transcript variant 1

0.02

1.5

ZNF587

Zinc finger protein 587 (ZNF587) transcript variant 1

0.025

2.8

RGS2

Regulator of G-protein signalling 2. 24kDa (RGS2)

0.03

4.8

CR2

CR2/CD21/C3d/Epstein-Barr virus receptor mRNA. complete cds. [M26004]

0.034

2.5

DNAJA1

DnaJ (Hsp40) homolog. subfamily A. member 1 (DNAJA1)

0.034

3.3

HSPA1L

Heat shock 70kDa protein 1-like (HSPA1L)

0.034

3.1

MICB

MHC class I polypeptide-related sequence B (MICB)

0.034

1.4

RACGAP1

Rac GTPase activating protein 1 (RACGAP1)

0.034

2.1

ZNF473

Zinc finger protein 473 (ZNF473). transcript variant 1

0.034

1.7

DNAJB12

DnaJ (Hsp40) homolog. subfamily B. member 12 (DNAJB12). transcript variant 1

0.035

1.6

HSP90AA1

Heat shock protein 90kDa alpha (cytosolic). class A member 1 (HSP90AA1) transcript variant 2

0.045

5.3

PPARBP

PPAR binding protein. mRNA (cDNA clone IMAGE:4822636). complete cds. [BC060758]

0.045

1.7

CCDC12

Coiled-coil domain containing 12 (CCDC12)

0.046

1.8

HSPA4L

Heat shock 70kDa protein 4-like (HSPA4L)

0.046

3.6

15 Genes down-regulated following 17AAG treatment

Gene name

Description

FDR

Fold Change

PLK3

Polo-like kinase 3 (Drosophila) (PLK3)

0.025

5.8

TMEM129

Transmembrane protein 129 (TMEM129)

0.027

2.2

IER3

Immediate early response 3 (IER3). transcript variant short

0.032

8.7

CCND1

Cyclin D1 (CCND1)

0.034

5.5

JUNB

Jun B proto-oncogene (JUNB)

0.034

5

TSEN2

tRNA splicing endonuclease 2 homolog (S. cerevisiae) (TSEN2)

0.034

2.8

CCDC85B

Coiled-coil domain containing 85B (CCDC85B)

0.035

2.3

WDR4

WD repeat domain 4 (WDR4). transcript variant 2

0.035

2.5

RFC4

Replication factor C (activator 1) 4. 37kDa (RFC4). transcript variant 1

0.044

2.2

PYCRL

Pyrroline-5-carboxylate reductase-like (PYCRL)

0.045

2.9

SHMT2

Serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2)

0.045

1.7

C6orf203

Chromosome 6 open reading frame 203 (C6orf203)

0.046

2.2

MAN1B1

Mannosidase. alpha. class 1B. member 1 (MAN1B1)

0.046

2.2

NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor. alpha (NFKBIA)

0.047

4.2

SFT2D3

SFT2 domain containing 3 (SFT2D3)

0.047

1.9