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Table 4 53 targets over-represented in ROS-diabetes literature

From: Literature-based discovery of diabetes- and ROS-related targets

Rank Symbol HUGO_ID Name #Paper BG #1 BG #2 BG #3
1 SOD1 11179 superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) 368 3.1E-84 2.0E-78 2.0E-78
2 CAT 1516 catalase 241 2.1E-50 3.9E-44 3.9E-44
3 NOX5 14874 NADPH oxidase, EF-hand calcium binding domain 5 177 3.1E-42 3.6E-39 2.1E-37
4 INS 6081 insulin 503 5.9E-41 2.0E-43 2.3E-39
5 XDH 12805 xanthine dehydrogenase 133 1.5E-30 1.2E-28 8.8E-28
6 PRKCA 9393 protein kinase C, alpha 194 7.1E-23 6.4E-26 8.9E-24
7 NCF1 7660 neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) 72 7.6E-19 7.7E-16 8.7E-16
8 NOS3 7876 nitric oxide synthase 3 (endothelial cell) 115 1.6E-18 3.9E-16 7.6E-18
9 SOD2 11180 superoxide dismutase 2, mitochondrial 85 2.1E-18 7.7E-16 3.8E-15
10 CYBA 2577 cytochrome b-245, alpha polypeptide 69 4.2E-17 5.0E-13 6.9E-14
11 NOS2A 7873 nitric oxide synthase 2A (inducible, hepatocytes) 144 3.9E-16 5.2E-12 4.5E-14
12 AGT 333 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 131 1.8E-14 1.4E-09 3.5E-08
13 AKR1B1 381 aldo-keto reductase family 1, member B1 (aldose reductase) 61 8.0E-13 9.5E-13 3.6E-11
14 CYBB 2578 cytochrome b-245, beta polypeptide (chronic granulomatous disease) 49 4.0E-12 2.6E-09 5.8E-11
15 NOS1 7872 nitric oxide synthase 1 (neuronal) 82 4.9E-12 3.7E-10 4.7E-09
16 NCF2 7661 neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2) 50 2.4E-11 1.5E-09 3.8E-08
17 CYCS 19986 cytochrome c, somatic 81 8.7E-10 2.2E-10 2.1E-10
18 HBB 4827 hemoglobin, beta 101 1.4E-08 5.9E-10 2.2E-08
19 GSR 4623 glutathione reductase 61 1.4E-08 4.8E-08 4.8E-08
20 UCP1 12517 uncoupling protein 1 (mitochondrial, proton carrier) 38 4.1E-07 2.1E-06 9.7E-06
21 NOX4 7891 NADPH oxidase 4 31 6.2E-07 2.3E-04 2.7E-05
22 PARP1 270 poly (ADP-ribose) polymerase family, member 1 37 7.1E-07 1.1E-07 5.3E-05
23 UCP2 12518 uncoupling protein 2 (mitochondrial, proton carrier) 34 7.0E-07 4.5E-06 2.1E-05
24 HBA1 4823 hemoglobin, alpha 1 30 1.1E-06 1.2E-06 9.3E-06
25 ALB 399 albumin 179 7.0E-06 4.9E-06 1.7E-06
26 NOX1 7889 NADPH oxidase 1 30 8.2E-06 8.6E-06 9.7E-06
27 NFKB1 7794 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) 90 9.4E-06 1.2E-04 4.5E-04
28 VEGFA 12680 vascular endothelial growth factor A 57 2.6E-04 1.9E-04 4.1E-03
29 SOD3 11181 superoxide dismutase 3, extracellular 18 2.5E-04 8.1E-02 3.4E-02
30 REN 9958 renin 51 3.6E-04 2.2E-02 7.2E-02
31 MPO 7218 myeloperoxidase 28 5.7E-04 2.4E-01 5.1E-02
32 SORD 11184 sorbitol dehydrogenase 15 1.8E-03 1.9E-03 1.8E-03
33 COL4A1 2202 collagen, type IV, alpha 1 15 1.8E-03 1.3E-02 1.8E-03
34 TGFA 11765 transforming growth factor, alpha 46 2.1E-03 3.5E-02 3.5E-04
35 ACE 2707 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 69 3.8E-03 1.1E-02 1.1E-02
36 AGTR1 336 angiotensin II receptor, type 1 36 3.7E-03 4.9E-02 1.8E-03
37 G6PD 4057 glucose-6-phosphate dehydrogenase 19 5.6E-03 3.7E-01 2.1E-01
38 CP 2295 ceruloplasmin (ferroxidase) 13 6.2E-03 3.1E-01 2.9E-01
39 NCF4 7662 neutrophil cytosolic factor 4, 40kDa 16 6.7E-03 9.9E-04 9.9E-04
40 MT-CYB 7427 mitochondrially encoded cytochrome b 15 1.3E-02 1.3E-02 1.3E-01
41 DUOX1 3062 dual oxidase 1 11 2.2E-02 2.9E-01 1.1E-01
42 SERPINE1 8583 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 37 2.4E-02 2.5E-02 1.1E-03
43 GSTCD 25806 glutathione S-transferase, C-terminal domain containing 37 2.4E-02 3.8E-01 9.1E-02
44 COQ7 2244 coenzyme Q7 homolog, ubiquinone (yeast) 16 2.8E-02 1.9E-01 3.1E-02
45 RAC1 9801 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 18 3.0E-02 4.3E-01 7.8E-02
46 MAOB 6834 monoamine oxidase B 10 3.9E-02 4.1E-01 4.4E-01
47 UCP3 12519 uncoupling protein 3 (mitochondrial, proton carrier) 17 4.7E-02 1.7E-02 1.8E-02
48 VCAM1 12663 vascular cell adhesion molecule 1 29 5.4E-02 6.3E-02 3.5E-02
49 AKT1 391 v-akt murine thymoma viral oncogene homolog 1 75 5.5E-02 4.9E-02 6.4E-02
50 LEPR 6554 leptin receptor 21 8.7E-02 3.1E-01 1.4E-02
51 EDN1 3176 endothelin 1 38 8.8E-02 3.8E-01 2.6E-02
52 COL1A1 2197 collagen, type I, alpha 1 84 8.7E-02 2.6E-02 1.7E-01
53 CCL2 10618 chemokine (C-C motif) ligand 2 38 2.0E-01 4.9E-02 1.0E-02
  1. '#Paper' is the number of papers in ROS-diabetes corpus; BG#1, BG#2 and BG#3 are Benjamini-Hochberg adjusted p-values between ROS-diabetes targets and background sets.