Table 4 53 targets over-represented in ROS-diabetes literature
From: Literature-based discovery of diabetes- and ROS-related targets
Rank | Symbol | HUGO_ID | Name | #Paper | BG #1 | BG #2 | BG #3 |
|---|---|---|---|---|---|---|---|
1 | SOD1 | 11179 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 368 | 3.1E-84 | 2.0E-78 | 2.0E-78 |
2 | CAT | 1516 | catalase | 241 | 2.1E-50 | 3.9E-44 | 3.9E-44 |
3 | NOX5 | 14874 | NADPH oxidase, EF-hand calcium binding domain 5 | 177 | 3.1E-42 | 3.6E-39 | 2.1E-37 |
4 | INS | 6081 | insulin | 503 | 5.9E-41 | 2.0E-43 | 2.3E-39 |
5 | XDH | 12805 | xanthine dehydrogenase | 133 | 1.5E-30 | 1.2E-28 | 8.8E-28 |
6 | PRKCA | 9393 | protein kinase C, alpha | 194 | 7.1E-23 | 6.4E-26 | 8.9E-24 |
7 | NCF1 | 7660 | neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) | 72 | 7.6E-19 | 7.7E-16 | 8.7E-16 |
8 | NOS3 | 7876 | nitric oxide synthase 3 (endothelial cell) | 115 | 1.6E-18 | 3.9E-16 | 7.6E-18 |
9 | SOD2 | 11180 | superoxide dismutase 2, mitochondrial | 85 | 2.1E-18 | 7.7E-16 | 3.8E-15 |
10 | CYBA | 2577 | cytochrome b-245, alpha polypeptide | 69 | 4.2E-17 | 5.0E-13 | 6.9E-14 |
11 | NOS2A | 7873 | nitric oxide synthase 2A (inducible, hepatocytes) | 144 | 3.9E-16 | 5.2E-12 | 4.5E-14 |
12 | AGT | 333 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 131 | 1.8E-14 | 1.4E-09 | 3.5E-08 |
13 | AKR1B1 | 381 | aldo-keto reductase family 1, member B1 (aldose reductase) | 61 | 8.0E-13 | 9.5E-13 | 3.6E-11 |
14 | CYBB | 2578 | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 49 | 4.0E-12 | 2.6E-09 | 5.8E-11 |
15 | NOS1 | 7872 | nitric oxide synthase 1 (neuronal) | 82 | 4.9E-12 | 3.7E-10 | 4.7E-09 |
16 | NCF2 | 7661 | neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2) | 50 | 2.4E-11 | 1.5E-09 | 3.8E-08 |
17 | CYCS | 19986 | cytochrome c, somatic | 81 | 8.7E-10 | 2.2E-10 | 2.1E-10 |
18 | HBB | 4827 | hemoglobin, beta | 101 | 1.4E-08 | 5.9E-10 | 2.2E-08 |
19 | GSR | 4623 | glutathione reductase | 61 | 1.4E-08 | 4.8E-08 | 4.8E-08 |
20 | UCP1 | 12517 | uncoupling protein 1 (mitochondrial, proton carrier) | 38 | 4.1E-07 | 2.1E-06 | 9.7E-06 |
21 | NOX4 | 7891 | NADPH oxidase 4 | 31 | 6.2E-07 | 2.3E-04 | 2.7E-05 |
22 | PARP1 | 270 | poly (ADP-ribose) polymerase family, member 1 | 37 | 7.1E-07 | 1.1E-07 | 5.3E-05 |
23 | UCP2 | 12518 | uncoupling protein 2 (mitochondrial, proton carrier) | 34 | 7.0E-07 | 4.5E-06 | 2.1E-05 |
24 | HBA1 | 4823 | hemoglobin, alpha 1 | 30 | 1.1E-06 | 1.2E-06 | 9.3E-06 |
25 | ALB | 399 | albumin | 179 | 7.0E-06 | 4.9E-06 | 1.7E-06 |
26 | NOX1 | 7889 | NADPH oxidase 1 | 30 | 8.2E-06 | 8.6E-06 | 9.7E-06 |
27 | NFKB1 | 7794 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 90 | 9.4E-06 | 1.2E-04 | 4.5E-04 |
28 | VEGFA | 12680 | vascular endothelial growth factor A | 57 | 2.6E-04 | 1.9E-04 | 4.1E-03 |
29 | SOD3 | 11181 | superoxide dismutase 3, extracellular | 18 | 2.5E-04 | 8.1E-02 | 3.4E-02 |
30 | REN | 9958 | renin | 51 | 3.6E-04 | 2.2E-02 | 7.2E-02 |
31 | MPO | 7218 | myeloperoxidase | 28 | 5.7E-04 | 2.4E-01 | 5.1E-02 |
32 | SORD | 11184 | sorbitol dehydrogenase | 15 | 1.8E-03 | 1.9E-03 | 1.8E-03 |
33 | COL4A1 | 2202 | collagen, type IV, alpha 1 | 15 | 1.8E-03 | 1.3E-02 | 1.8E-03 |
34 | TGFA | 11765 | transforming growth factor, alpha | 46 | 2.1E-03 | 3.5E-02 | 3.5E-04 |
35 | ACE | 2707 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 69 | 3.8E-03 | 1.1E-02 | 1.1E-02 |
36 | AGTR1 | 336 | angiotensin II receptor, type 1 | 36 | 3.7E-03 | 4.9E-02 | 1.8E-03 |
37 | G6PD | 4057 | glucose-6-phosphate dehydrogenase | 19 | 5.6E-03 | 3.7E-01 | 2.1E-01 |
38 | CP | 2295 | ceruloplasmin (ferroxidase) | 13 | 6.2E-03 | 3.1E-01 | 2.9E-01 |
39 | NCF4 | 7662 | neutrophil cytosolic factor 4, 40kDa | 16 | 6.7E-03 | 9.9E-04 | 9.9E-04 |
40 | MT-CYB | 7427 | mitochondrially encoded cytochrome b | 15 | 1.3E-02 | 1.3E-02 | 1.3E-01 |
41 | DUOX1 | 3062 | dual oxidase 1 | 11 | 2.2E-02 | 2.9E-01 | 1.1E-01 |
42 | SERPINE1 | 8583 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 37 | 2.4E-02 | 2.5E-02 | 1.1E-03 |
43 | GSTCD | 25806 | glutathione S-transferase, C-terminal domain containing | 37 | 2.4E-02 | 3.8E-01 | 9.1E-02 |
44 | COQ7 | 2244 | coenzyme Q7 homolog, ubiquinone (yeast) | 16 | 2.8E-02 | 1.9E-01 | 3.1E-02 |
45 | RAC1 | 9801 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 18 | 3.0E-02 | 4.3E-01 | 7.8E-02 |
46 | MAOB | 6834 | monoamine oxidase B | 10 | 3.9E-02 | 4.1E-01 | 4.4E-01 |
47 | UCP3 | 12519 | uncoupling protein 3 (mitochondrial, proton carrier) | 17 | 4.7E-02 | 1.7E-02 | 1.8E-02 |
48 | VCAM1 | 12663 | vascular cell adhesion molecule 1 | 29 | 5.4E-02 | 6.3E-02 | 3.5E-02 |
49 | AKT1 | 391 | v-akt murine thymoma viral oncogene homolog 1 | 75 | 5.5E-02 | 4.9E-02 | 6.4E-02 |
50 | LEPR | 6554 | leptin receptor | 21 | 8.7E-02 | 3.1E-01 | 1.4E-02 |
51 | EDN1 | 3176 | endothelin 1 | 38 | 8.8E-02 | 3.8E-01 | 2.6E-02 |
52 | COL1A1 | 2197 | collagen, type I, alpha 1 | 84 | 8.7E-02 | 2.6E-02 | 1.7E-01 |
53 | CCL2 | 10618 | chemokine (C-C motif) ligand 2 | 38 | 2.0E-01 | 4.9E-02 | 1.0E-02 |