Genotator: A disease-agnostic tool for genetic annotation of disease

BMC Medical Genomics

Table 5 Top 10 Parkinson's Disease Genes ranked on Genotator score.

Gene	Score	Literature Support	Reference	WRW Mention
LRRK2	105.1	Frequency of LRRK2 mutations in early-and late-onset Parkinson disease.	[42]	Y
MAPT	60.8	Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy.	[43]	Y
SNCA	59.8	Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.	[44]	Y
PARK2	59.6	Case-control study of the parkin gene in early-onset Parkinson disease.	[45]	Y
APOE	34.7	Phenotypic associations of tau and ApoE in Parkinson's disease.	[46]
GBA	21.4	Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset.	[47]	Y
BDNF	19.5	BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease.	[48]
DRD2	18.7	Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease.	[49]
MAOB	17.1	Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups.	[50]
PINK1	16.8	Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control.	[51]	Y

The table lists the title and reference of the research study supporting the gene-disease association together with the official gene symbol. We used the recent review article by Wider, Ross, and Wszolek (2010) as a source for the most promising Parkinson's disease gene candidates (WRW Mention). A complete set of results is available online as Additional file 2.

ISSN: 1755-8794