Gene-set enrichment analysis. Gene-set enrichment analysis against the KEGG database for differentially enriched pathways in whole blood between obese and lean subjects. Enrichment plots for the 3 pathways upregulated in the obese cohort are shown on the left side with the relative gene positions indicated by the straight lines (line plot) under each graph. Lines clustered to the left represent higher ranked genes in the ranked list. Expression profiles for a subset of genes (shaded in yellow in the line plots) contributing to core enrichment for each pathway are shown to the right as a heatmap. The heatmap compares subject-level gene expression in both obese and lean subjects. Gene expression is normalized for each row. Lower levels of expression are represented in shades of blue and higher expression in red.