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Figure 4 | BMC Medical Genomics

Figure 4

From: Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies

Figure 4

GSEA reveals similarities between the genes being upregulated in ALL with 11q23/ MLL and those upregulated in normal prostate tissues. A) Heat map of the top ranked 50 up- and downregulated genes in 11q23/MLL-positive ALL. B) Enrichment plot showing the enrichment of genes upregulated in normal prostate tissue among the upregulated genes in ALLs with 11q23/MLL. For an explanation about the enrichment plot, see the legend to Figure 3B. C) Heat map of the core enrichment genes in the ALL data set. D) Heat map of the same core enrichment genes in the normal tissue data, the order of the core enrichment genes are the same as in C. When comparing figures C and D, the similarity of the 11q23/MLL and the prostate tissue gene expression profiles can be easily appreciated, indicating a shared transcriptional program.

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BMC Medical Genomics

ISSN: 1755-8794

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