| |
IGF1 level
|
IGFBP3 level
|
IGFratio
|
PDENa
|
ABDENb
|
---|
IGF1
| | | | | | |
---|
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. CG
|
0,1185
|
0.5553
|
0.9493
|
0.6462
|
0.2337
|
0.2693
|
2. CA
|
0,21486
|
0.1424
|
0.5075
|
0.4549
|
0.5147
|
0.6701
|
3. TA
|
0,61718
|
0.7733
|
0.7103
|
0.9016
|
0.4486
|
0.8462
|
4. TG
|
0,04947
|
0.1683
|
0.7237
|
0.2713
|
0.1737
|
0.0334
|
Global association
| |
0.3342
|
0.924
|
0.6641
|
0.3069
|
0.1167
|
IGF2
| | | | | | |
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. TG
|
0,34537
|
0.2769
|
0.9845
|
0.1648
|
0.2297
|
0.4051
|
2. CG
|
0,27102
|
0.6093
|
0.1440
|
0.3058
|
0.5776
|
0.7190
|
3. TA
|
0,27821
|
0.7660
|
0.9920
|
0.5860
|
0.5254
|
0.6165
|
4. CA
|
0,10541
|
0.0014
|
0.0181
|
0.0974
|
0.8518
|
0.9403
|
Global association
| |
0.0138
|
0.0408
|
0.2712
|
0.6353
|
0.8313
|
IGF1R
| | | | | | |
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. GGAGATGT
|
0,09532
|
0.8216
|
0.6761
|
0.7512
|
0.8689
|
0.9008
|
2. GGAGATAG
|
0,07847
|
0.1245
|
0.0885
|
0.5697
|
0.1153
|
0.1678
|
3. GGAGACGT
|
0,12829
|
0.8324
|
0.9646
|
0.9343
|
0.4403
|
0.6585
|
4. GGAAGCAG
|
0,05028
|
0.4479
|
0.6971
|
0.4485
|
0.7200
|
0.8879
|
5. GGAGACAG
|
0,10502
|
0.8550
|
0.9531
|
0.8820
|
0.1567
|
0.2125
|
Global association
| |
0.5384
|
0.5162
|
0.8893
|
0.3016
|
0.4638
|
IGF2R
| | | | | | |
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. GAATACC
|
0,06242
|
0.0397
|
0.1228
|
0.2853
|
0.2140
|
0.0784
|
2. AGGCGCC
|
0,27961
|
0.2376
|
0.3324
|
0.5912
|
0.7018
|
0.6786
|
3. GAGCGTC
|
0,06251
|
0.7378
|
0.8651
|
0.9925
|
0.9465
|
0.7463
|
4. GAATGCC
|
0,11233
|
0.4057
|
0.4787
|
0.9129
|
0.7414
|
0.5293
|
5. AGATGCC
|
0,2451
|
0.0455
|
0.0631
|
0.4429
|
0.7105
|
0.8569
|
6. AGATACC
|
0,07038
|
0.4484
|
0.3361
|
0.8486
|
0.9180
|
0.8191
|
7. GAGCGCT
|
0,06327
|
0.5430
|
0.4985
|
0.6552
|
0.0575
|
0.0622
|
Global association
| |
0.0524
|
0.1619
|
0.8720
|
0.5036
|
0.2659
|
IGFals
| | | | | | |
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. CTC
|
0,08951
|
0.8055
|
0.0582
|
0.2993
|
0.4069
|
0.5648
|
2. CCC
|
0,69765
|
0.2290
|
0.6156
|
0.3095
|
0.8880
|
0.9099
|
3. CCT
|
0,21171
|
0.1412
|
0.0769
|
0.6082
|
0.6291
|
0.7605
|
Global association
| |
0.3387
|
0.0523
|
0.4678
|
0.6624
|
0.8261
|
IGFBP3
| | | | | | |
Haplotype
|
Frequency
|
p-value
|
p-value
|
p-value
|
p-value
|
p-value
|
1. AG
|
0,17767
|
0.1630
|
0.0009
|
0.1595
|
0.5689
|
0.2204
|
2. AC
|
0,81917
|
0.1635
|
0.0008
|
0.1531
|
0.5551
|
0.2302
|
Global association
| |
0.1630
|
0.0009
|
0.1595
|
0.5689
|
0.2204
|
- All associations are adjusted by age and BMI. Significant p-values (< 0,05) are marked in bold italics.
-
aPDEN: Percent Density.
-
bABDEN: Absolute Density, measured in cm2.