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Table 3 Associations of the common haplotypes with IGF1, IGFBP3 and mammographic density levels.

From: Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

   IGF1 level IGFBP3 level IGFratio PDENa ABDENb
IGF1       
Haplotype Frequency p-value p-value p-value p-value p-value
1. CG 0,1185 0.5553 0.9493 0.6462 0.2337 0.2693
2. CA 0,21486 0.1424 0.5075 0.4549 0.5147 0.6701
3. TA 0,61718 0.7733 0.7103 0.9016 0.4486 0.8462
4. TG 0,04947 0.1683 0.7237 0.2713 0.1737 0.0334
Global association   0.3342 0.924 0.6641 0.3069 0.1167
IGF2       
Haplotype Frequency p-value p-value p-value p-value p-value
1. TG 0,34537 0.2769 0.9845 0.1648 0.2297 0.4051
2. CG 0,27102 0.6093 0.1440 0.3058 0.5776 0.7190
3. TA 0,27821 0.7660 0.9920 0.5860 0.5254 0.6165
4. CA 0,10541 0.0014 0.0181 0.0974 0.8518 0.9403
Global association   0.0138 0.0408 0.2712 0.6353 0.8313
IGF1R       
Haplotype Frequency p-value p-value p-value p-value p-value
1. GGAGATGT 0,09532 0.8216 0.6761 0.7512 0.8689 0.9008
2. GGAGATAG 0,07847 0.1245 0.0885 0.5697 0.1153 0.1678
3. GGAGACGT 0,12829 0.8324 0.9646 0.9343 0.4403 0.6585
4. GGAAGCAG 0,05028 0.4479 0.6971 0.4485 0.7200 0.8879
5. GGAGACAG 0,10502 0.8550 0.9531 0.8820 0.1567 0.2125
Global association   0.5384 0.5162 0.8893 0.3016 0.4638
IGF2R       
Haplotype Frequency p-value p-value p-value p-value p-value
1. GAATACC 0,06242 0.0397 0.1228 0.2853 0.2140 0.0784
2. AGGCGCC 0,27961 0.2376 0.3324 0.5912 0.7018 0.6786
3. GAGCGTC 0,06251 0.7378 0.8651 0.9925 0.9465 0.7463
4. GAATGCC 0,11233 0.4057 0.4787 0.9129 0.7414 0.5293
5. AGATGCC 0,2451 0.0455 0.0631 0.4429 0.7105 0.8569
6. AGATACC 0,07038 0.4484 0.3361 0.8486 0.9180 0.8191
7. GAGCGCT 0,06327 0.5430 0.4985 0.6552 0.0575 0.0622
Global association   0.0524 0.1619 0.8720 0.5036 0.2659
IGFals       
Haplotype Frequency p-value p-value p-value p-value p-value
1. CTC 0,08951 0.8055 0.0582 0.2993 0.4069 0.5648
2. CCC 0,69765 0.2290 0.6156 0.3095 0.8880 0.9099
3. CCT 0,21171 0.1412 0.0769 0.6082 0.6291 0.7605
Global association   0.3387 0.0523 0.4678 0.6624 0.8261
IGFBP3       
Haplotype Frequency p-value p-value p-value p-value p-value
1. AG 0,17767 0.1630 0.0009 0.1595 0.5689 0.2204
2. AC 0,81917 0.1635 0.0008 0.1531 0.5551 0.2302
Global association   0.1630 0.0009 0.1595 0.5689 0.2204
  1. All associations are adjusted by age and BMI. Significant p-values (< 0,05) are marked in bold italics.
  2. aPDEN: Percent Density.
  3. bABDEN: Absolute Density, measured in cm2.
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