Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

Biong, Margarethe; Gram, Inger T; Brill, Ilene; Johansen, Fredrik; Solvang, Hiroko K; Alnaes, Grethe IG; Fagerheim, Toril; Bremnes, Yngve; Chanock, Stephen J; Burdett, Laurie; Yeager, Meredith; Ursin, Giske; Kristensen, Vessela N

doi:10.1186/1755-8794-3-9

Table 3 Associations of the common haplotypes with IGF1, IGFBP3 and mammographic density levels.

From: Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

		IGF1 level	IGFBP3 level	IGFratio	PDEN^a	ABDEN^b
IGF1
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. CG	0,1185	0.5553	0.9493	0.6462	0.2337	0.2693
2. CA	0,21486	0.1424	0.5075	0.4549	0.5147	0.6701
3. TA	0,61718	0.7733	0.7103	0.9016	0.4486	0.8462
4. TG	0,04947	0.1683	0.7237	0.2713	0.1737	*0.0334*
Global association		0.3342	0.924	0.6641	0.3069	0.1167
IGF2
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. TG	0,34537	0.2769	0.9845	0.1648	0.2297	0.4051
2. CG	0,27102	0.6093	0.1440	0.3058	0.5776	0.7190
3. TA	0,27821	0.7660	0.9920	0.5860	0.5254	0.6165
4. CA	0,10541	*0.0014*	*0.0181*	0.0974	0.8518	0.9403
Global association		*0.0138*	*0.0408*	0.2712	0.6353	0.8313
IGF1R
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. GGAGATGT	0,09532	0.8216	0.6761	0.7512	0.8689	0.9008
2. GGAGATAG	0,07847	0.1245	0.0885	0.5697	0.1153	0.1678
3. GGAGACGT	0,12829	0.8324	0.9646	0.9343	0.4403	0.6585
4. GGAAGCAG	0,05028	0.4479	0.6971	0.4485	0.7200	0.8879
5. GGAGACAG	0,10502	0.8550	0.9531	0.8820	0.1567	0.2125
Global association		0.5384	0.5162	0.8893	0.3016	0.4638
IGF2R
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. GAATACC	0,06242	*0.0397*	0.1228	0.2853	0.2140	0.0784
2. AGGCGCC	0,27961	0.2376	0.3324	0.5912	0.7018	0.6786
3. GAGCGTC	0,06251	0.7378	0.8651	0.9925	0.9465	0.7463
4. GAATGCC	0,11233	0.4057	0.4787	0.9129	0.7414	0.5293
5. AGATGCC	0,2451	*0.0455*	0.0631	0.4429	0.7105	0.8569
6. AGATACC	0,07038	0.4484	0.3361	0.8486	0.9180	0.8191
7. GAGCGCT	0,06327	0.5430	0.4985	0.6552	0.0575	0.0622
Global association		0.0524	0.1619	0.8720	0.5036	0.2659
IGFals
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. CTC	0,08951	0.8055	0.0582	0.2993	0.4069	0.5648
2. CCC	0,69765	0.2290	0.6156	0.3095	0.8880	0.9099
3. CCT	0,21171	0.1412	0.0769	0.6082	0.6291	0.7605
Global association		0.3387	0.0523	0.4678	0.6624	0.8261
IGFBP3
Haplotype	Frequency	p-value	p-value	p-value	p-value	p-value
1. AG	0,17767	0.1630	*0.0009*	0.1595	0.5689	0.2204
2. AC	0,81917	0.1635	*0.0008*	0.1531	0.5551	0.2302
Global association		0.1630	*0.0009*	0.1595	0.5689	0.2204

All associations are adjusted by age and BMI. Significant p-values (< 0,05) are marked in bold italics.
^aPDEN: Percent Density.
^bABDEN: Absolute Density, measured in cm².

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ISSN: 1755-8794

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