Skip to main content
Figure 4 | BMC Medical Genomics

Figure 4

From: Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

Figure 4

Expression patterns of the SLC45A3-ELK4 e4-e2 TIC and related genes. (A) qRT-PCR levels of SLC45A3-ELK4 e4-e2 TIC in the sequenced prostate tumor and normal sample pairs T1/N1, T2/N2, and T3/N3 pairs (labeled as 1-3, and marked with "-" for ERG-negative and "+" for ERG-positive status), plus panels of 6 ERG-negative and 14 ERG-positive prostate tumor and normal matched samples, a commercial sample of prostate normal RNA, and 9 lung cancer cell lines. (B) Microarray-based expression profile of SLC45A3 (Affymetrix probe 228696-at on GeneChip HG-U133B) across human tissues, showing prostate specificity. Samples are organized by tissue, with normal samples above (green) and cancer samples below (red). (C) Microarray-based expression profile of ELK4 (Affymetrix probe 206919-at on GeneChip HG-U133A). (D) Relationship of SLC45A3 and ERG (Affymetrix probe set 241926-s-at on GeneChip HG-U133B) expression levels in prostate tumor and normal samples, showing that highest expression of SLC45A3 is restricted to samples with low expression of ERG.

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us