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Table 1 Comparison of Biobanks and Phenotypes Across the eMERGE sites

From: The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies

Site Biobank design Biobank size and demographics Phenotypic outcomes
Marshfield Population-based 20,000; 98% Caucasian, mean age 48, range 18-102 Low HDL cholesterol, cataract (n = 3968) Secondary: diabetic retinopathy
Mayo Clinic PAD cases identified from the Mayo non-invasive vascular laboratory database; control subjects without PAD identified from the Cardiovascular Health Clinic 1687 cases (mean age 65) and 1725 controls (mean age 60) Peripheral arterial disease (PAD) (n = 3412); Secondary: red blood cell indices
Northwestern Outpatient clinic and hospital-based Approximately 10,000; 12% African American, 8% Hispanic; Mean age 50, range 18 - 90+ Primary: type II diabetes (n = 3531); Secondary: lipids and height
Group Health ACT Study Cohort of aged 65 and olderrandomly sampled from an HMO all known not to be demented at enrollment and followed for development of dementia, and Alzheimer's Disease (source of cases and controls) ADPR: Alzheimer's disease cases from a model incidence case registry (source of cases) Approximately 4000 persons over age 65 from ACT Study Alzheimer Disease (n = 3390), carotid artery stenosis; Secondary: statin adverse events
Vanderbilt Use of discarded blood/non-human subjects linked to electronic medical records Approximately 75,000; 70% Caucasian, 10% African American; mean age 53, range 18-100 Electrocardiographic QRS duration (n = 3192); Secondary: PheWAS