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Table 1 Comparison of a standard deviation (SD) and signal to noise (S/N) ratio for a raw CN signal obtained using different types of references. Here SD is an average of all SDs obtained for each raw CN segmented region in log2 scale, and S/N is computed as a ratio of the difference between the raw CN values corresponding to CN = 3 and CN = 2 in log2 scale and the SD value defined above

From: A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples

FFPE Tumor vs: Blood normals (frozen) HapMap (frozen) FFPE normals VN based
SD (log2) 0.627 0.592 0.363 0.281
S/N ratio for CN = 3 (log2) 0.797 0.845 1.377 1.78