Figure 2

Local genetic architecture. Association p-values from multiple linear regression are shown based on physical position (NCBI build 36, dbSNP build 126). The light blue curve depicts the recombination rate from the combined Hap Map Phase II data. Linkage disequilibrium based on the HUFS sample is color-coded red for r ² to the top SNP ≥ 0.8, orange for r ² < 0.8 and ≥ 0.5, blue for r ² < 0.5 and ≥ 0.2, and gray for r ² < 0.20. Green arrows indicate the direction of transcription.