Figure 4

Gene expression for the top eight genes, NAB2 and LAMP2. Gene expression plots are shown for the top eight ranked genes, and NAB2 and LAMP2 genes are shown together, as these genes have known functions relevant to ISR. Gene expression data is shown for both cohorts across the time course of samples in each study. For each gene, expression levels are shown on the y-axis as the log 2 of normalized gene expression (GE), and the timepoints shown on the x-axis of each plot correspond to baseline (BL), early follow-up (EF), and late follow-up (LF) timepoints, although data was analyzed across the continuous timeframe of follow-up blood sampling, rather than categorically as is depicted here for illustration purposes. The box plots are plotted with the whiskers at 1.5 times the interquartile range.