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Table 4 Genes identified in figure 4 with p-value < 0.05 by t-test

From: An integrative approach to identifying cancer chemoresistance-associated pathways

Gene Symbol ovarian
p-value
lung
p-value
Betweenness
(mean = 3.8E-4)
Degree
(mean = 9.71E-4)
Connected nodes
KRAS
(v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)
6.23E-04 0.001393 0.00703 0.009226  
TP53
(tumor protein p53)
0.011083 1.82E-04 0.046039 0.029049  
AKT
(v-akt murine thymoma viral oncogene homolog)
1.87E-05 4.60E-06 0.009775 0.013091 V
GSK3β
(glycogen synthase kinase 3 beta)
3.09E-06 1.81E-04 0.003932 0.006483 V
WNT
(wingless-type MMTV integration site family)
0.009519 0.002234 1.51E-04 4.99E-04  
PTEN
(phosphatase and tensin homolog)
0.001494 0.016189 0.002282 0.002618 V
DVL
(dishevelled, dsh homolog 1 (Drosophila))
1.95E-08 1.80E-05 0.001653 0.002618 V
HES1
(hairy and enhancer of split 1, (Drosophila))
0.005831 2.82E-07 4.08E-04 0.001745  
  1. Genes listed in table 4 are significant in both ovarian and lung expression data with p-value < 0.05. Four connected nodes were identified. These genes also had significant betweenness and degree centrality. PTEN was the first tumor suppressor gene to be identified in the phosphatase family, and the principal function of its gene product appears to be dephosphorylation of the second messenger PIP3 [43]. The expression of PTEN in two independent glioblastoma cell lines results in the disruption of downstream signaling of PI3K to Akt and Bad [44]. Thus, when PTEN is present, Akt phosphorylation is blocked and apoptosis mechanisms may be activated. The importance of Akt and PTEN genes are as well revealed by this work, which illustrates the accuracy and efficiency of our algorithm.