Figure 3

The tumor-immunity interactome landscape. A three-dimensional surface plot representing the landscape of degree centrality (connectivity) of the interactome in the context of immune and cancer relevance: All axes are on the log scale and values above one on the log scale were considered high in terms of immune and cancer relevance. The consideration of one on the log scale as high in terms of immune relevance is made on the basis of the average immune scores for the expert sources ranging from 1 bit and above (see Figure 2). The color scale in the heatmap is representative of the connectivity of each gene in the human interactome. That which is apparent is the distinct areas of scattered high and low connectivity for genes in the cancer-immune landscape. The underlying data for this plot is detailed in Additional File 5.