Comparison of the immunological component of skin cancer and states of melanoma progression. A heatmap of the average bits of immune information of the differentially expressed genes (> 2 times fold-change) among the pairwise comparisons of normal skin and skin cancer states. The labels from the left to right columns refer to normal skin tissues: ("Normal"), normal melanocyte ("Melanocyte") and then various states of skin cancer: primary melanoma ("Primary"), squamous cell carcinoma ("Squamous"), basal cell carcinoma ("Basal"), in-situ melanoma ("In Situ") and metastatic melanoma ("Metastatic"). Distinct differences in the immunological component of the various skin cancer and normal states are detected. We have focused here as an example, on the comparison between metastatic melanoma and normal human melanocytes. A subnetwork module from the interactome landscape of those genes with high immunological relevance is displayed. Upregulated genes are color-coded red and downregulated genes are color-coded green in this network. The size of a gene is proportional to the immunological relevance of the gene. There is clearly increased T-cell activity such as the presence of increased expression of CD8, CD4 and CD3 T-cell markers. This coincides with upregulation of key chemokine and cytokine interactions.