Most frequently selected modules and clinical variables that build successful combined models for all patients (A) and ER-positive patients (B). Modules in blue identify those modules and/or clinical variables that were evaluated in the combined model in Fig. 2. Colored squares identify the modules and/or clinical variables association with either poor (red) or good (green) prognosis. Freq, frequency of selection of a particular module/clinical variable among 200 successful models; Ref, references of previously published modules.