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Figure 2 | BMC Medical Genomics

Figure 2

From: Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors

Figure 2

Analysis Pipeline. In a preprocessing step, validated SNPs and focal CNAs are combined into a mutation matrix. This matrix is fed into the winnow algorithm, which scores each gene pair by exclusivity, indicated by edge scores in a graph. This graph is then searched for modules up to a specified size and the algorithmic significance is calculated for each potential module. Finally, the most significant modules are reported.

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