Tumor Microenvironment
|
Test
|
Number of genes < 0.001 and
(<0.05 total/annotated)*
|
Pt p-value
for <0.001 cutoff†
|
---|
Four way
|
F test
|
1,132
|
< 0.001
|
PBS vs PHY906
|
t test
|
117/113 (1,759/1,664)
|
< 0.001
|
PBS vs CPT-11
|
t test
|
570/557 (2,630/2,513)
|
< 0.001
|
PBS vs CPT-11+PHY906
|
t test
|
798/774 (3,347/3,190)
|
< 0.001
|
CPT-11 vs CPT-11+PHY906
|
t test
|
93/91 (1,556/1,477)
|
< 0.001
|
-
Number of sample: PBS = 10; PHY906 = 9; CPT-11
= 10;
CPT-11 + PHY906 = 9; Total 38
- *Cutoff of p-value < 0.05 was used to select genes for IPA; In parentheses are the number of genes identified at <0.05 level and with an annotated function that could be used for IPA; †although the pt test p-value is shown for the <0.001 analyses, identical results were obtained for the lower stringency analyses. Details concerning comparisons among other tissues and treatments are provided in the extended table as an additional file (Additional file 2, Table S2).
- Note. Pt test: permutation test