Figure 3

Network analysis of genes Not Normalized. Genes and expression values from the Not Normalized category were examined for networks of interrelated genes using Ingenuity Pathway Analysis software. One significant network was centered around Pdgf, Nfkb, and Jnk. Expression values for the control versus diabetic groups is presented in A and for the insulin-treated diabetic versus diabetic comparison in B. Relationships are presented as lines and arrows. Red lines represent activation or positive regulation of expression while green lines indicate inhibition or negative regulation of expression. Grey lines are known protein-protein interactions and dashed lines are indirect relationships. Gene symbols are coded as green for significantly reduced expression, red for significantly reduced expression, and white for no change in expression.