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Figure 6 | BMC Medical Genomics

Figure 6

From: Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome

Figure 6

Transcript dysregulation not prevented by insulin treatment. In qPCR confirmation experiments, a set of genes was observed which were unaltered in expression after one month of diabetes but were differentially expressed at in both diabetic and insulin-treated diabetic groups at three months. This 'not prevented' phenotype was evident in the increased expression of Ccr5, Jak3, Qprt, and Ssh3 genes. One-way ANOVA, Student Newman Keuls pair-wise post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001 for 3 month data; n = 7-11/group. ND - Non-Diabetic control, D - Diabetic, D+I - Insulin-treated Diabetic, 1 M - 1 month, 3 M - 3 Months.

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