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Figure 7 | BMC Medical Genomics

Figure 7

From: Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome

Figure 7

Transcript dysregulation partially prevented by insulin treatment. A set of gene in the qPCR experiments presented a 'partially prevented' phenotype in which gene expression changes in diabetic animals were significantly ameliorated by insulin treatment but altered expression from control animals was still evident. Increased expression of A2 m, Fabp7, and Gfap was reduced by insulin treatment but was still significantly higher than in the control group. Similarly, Npr3 expression in the insulin-treated diabetic rats was not significantly different from that in control rats, nor was it significantly different from the diabetic rats. One-way ANOVA, Student Newman Keuls pair-wise post-hoc test, *P < 0.05, ***P < 0.001 for 3 month data; n = 7-11/group. ND - Non-Diabetic control, D - Diabetic, D+I - Insulin-treated Diabetic, 1 M - 1 month, 3 M - 3 Months.

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