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Table 1 List of sense-AFAS probe pairs detecting altered expression balances in normal tissue and cancer tissue in patients with colon cancer based on the random priming approach

From: Comprehensive expressional analyses of antisense transcripts in colon cancer tissues using artificial antisense probes

AFAS ID Diff. (%) Annotation
X07876-03 97.2 wingless-type MMTV integration site family member 2
L31951-03 94.1 mitogen-activated protein kinase 9
U29343-04 74.6 hyaluronan-mediated motility receptor (RHAMM)
U09304-01 63.3 ephrin-B1
U43746-02 62.6 breast cancer 2, early onset
X63629-03 57.8 cadherin 3, type 1, P-cadherin (placental)
M25753-01 54.5 cyclin B1
U69611-04 50.7 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
M63167-01 47.9 v-akt murine thymoma viral oncogene homolog 1
M77830-02 43.9 desmoplakin (DPI, DPII)
M29366-04 40.9 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
M15990-01 39.3 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
X53586-04 38.4 integrin, alpha 6
U43746-15 37.1 breast cancer 2, early onset
J04088-07 36.5 topoisomerase (DNA) II alpha (170 kD)
X87852-02 36.5 plexin A3
X05232-03 32.7 matrix metalloproteinase 3 (stromelysin 1, progelatinase)
M29039-02 32.7 jun B proto-oncogene
X80343-01 32.4 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
L34058-01 30.3 cadherin 13, H-cadherin (heart)
Y10479-01 30.3 E2F transcription factor 3
M14505-02 29.7 cyclin-dependent kinase 4
J02958-06 29.7 met proto-oncogene (hepatocyte growth factor receptor)
U43746-11 29.1 breast cancer 2, early onset
U58334-01 29.1 tumor protein p53 binding protein, 2
X63629-01 28.5 cadherin 3, type 1, P-cadherin (placental)
U58334-02 28.2 tumor protein p53 binding protein, 2
X56654-01 27.9 desmoglein 1
M81934-01 27.6 cell division cycle 25B
X66363-03 27.6 PCTAIRE protein kinase 1
M26880-04 26.8 ubiquitin C
U37139-02 25.6 integrin beta 3 binding protein (beta3-endonexin)
L29222-02 24.2 CDC-like kinase 1
U01038-02 21.9 polo-like kinase (Drosophila)
M35410-02 21.1 insulin-like growth factor binding protein 2 (36 kD)
M35296-07 18.9 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
AF022385-02 18.6 programmed cell death 10
M30704-01 17.5 amphiregulin (schwannoma-derived growth factor)
U43142-01 16.1 vascular endothelial growth factor C
M32315-05 15.9 tumor necrosis factor receptor superfamily, member 1B
M85289-12 15.9 heparan sulfate proteoglycan 2 (perlecan)
AB000220-03 13.5 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
U29343-01 11.2 hyaluronan-mediated motility receptor (RHAMM)
NM_005417-02 10.7 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
U16752-04 70.2 stromal cell-derived factor 1
D21337-07 35.2 collagen, type IV, alpha 6
Y00815-03 16.9 protein tyrosine phosphatase, receptor type, F
X04571-05 13.8 epidermal growth factor (beta-urogastrone)
L12002-06 10.9 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
  1. Identification (ID) of only the AFAS probes is shown. The format of the ID is: NCBI accession number of sense gene-serial number given to the AFAS probes, starting from the 5' end of the antisense region. Thus, the ID for the corresponding sense gene can be inferred from the AFAS probe ID. The column "Diff." denotes the minimum percentage of the differences in expression intensities between normal tissue, cancer tissue, and those obtained by using sense probes, and AFAS probes. Only the third greatest value among six values for each patient is shown. The first 44 rows show the list of sense-AFAS probe pairs detecting up-regulated expression of the sense transcript and down-regulated expression of the AFAS transcript in cancer tissues. The last five rows show the list of sense-AFAS probe pairs detecting down-regulated expression of the sense gene and up-regulated expression of the AFAS gene in cancer tissues. These two lists are separated by a line.
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BMC Medical Genomics

ISSN: 1755-8794

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