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Table 3 Gene ontology (GO) terms for miRNA-targets in the category of biological processes

From: Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer

Cancer-related and down-regulated miRNA

miRNA family

No. of mRNAs

GO terms

hsa-let-7 g

Let-7 g

16

Anaphase-promoting complex(APC)-dependent proteasomal ubiquitin-dependent protein catabolic process, response to oxidative stress and regulation of apoptosis

hsa-miR-101

miR-101

7

Ubiquitin-dependent protein catabolic process, APC-dependent proteasonmal ubiquitin-dependent protein catabolic process and oxidoreductase activity

hsa-miR-133a

miR-133

17

Polyamine biosynthetic process,glutathione peroxidase process, Ubiquitin-dependent protein catabolic process and regulation of apoptosis

hsa-miR-150

miR-150

20

Polyamine biosynthetic process, APC-dependent proteasomal ubiquitin-dependent protein catabolic process, Glutathione peroxidase activity

hsa-miR-15a

miR-15

8

Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, response to oxidative stress and proteasome complex

hsa-miR-16

miR-16

8

APC-dependent proteasomal ubiquitin-dependent protein catabolic process, negative regulation of cell proliferation and oxidoreductase activity

hsa-miR-29b

miR-29

15

Regulation of cell proliferation, glutathione peroxidase activity and regulation of apoptosis

hsa-miR-29c

miR-29

7

Ubiquitin-dependent protein catabolic process, APC-dependent proteasomal ubiquitin-dependent protein catabolic process and translational elongation

hsa-miR-30a

miR-30

22

Polyamine biosynthetic process, ubiquitin-dependent protein catabolic process, and regulation of apoptosis

hsa-miR-30b

miR-30

20

Ubiquitin-dependent protein catabolic process, polyamine biosynthetic process and oxidative stress

hsa-miR-30c

miR-30

15

Polyamine biosynthetic process, ubiquitin-dependent protein catabolic process, and regulation of apoptosis

hsa-miR-30d

miR-30

25

Regulation of apoptosis, glutathione peroxidase activity and ubiquitin-dependent protein catabolic process

hsa-miR-30e

miR-30

17

Polyamine biosynthetic process, response to oxidative stress and regulation of apoptosis

hsa-miR-34b

miR-34

12

Regulation of cell proliferation, oxidoreductase activity and translational elongation

mmu-miR-342

miR-342

21

Polyamine biosynthetic process, translational elongation and APC-dependent proteasomal ubiquitin-dependent protein catabolic process