From: Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer
Top Network | Target genes | Top functions | The nos. of miRNAs associated |
---|---|---|---|
Network 1 | BHLHE40, CANX, CDC42SE1, GPX1, GPX4, GSTP1, MDK, MIF, MMP11, OAZ1, ODC1, PPIB, PRDX2, PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8, TGFBI, UBE2I | small molecule biochemistry, drug metabolism and tumor morphology | 15 |
Network 2 | ANXA2, CAPG, CLIC1, CPNE1, CSTB, DAP, EIF3B, GUK1, IFITM1, RPL34, RPS9, SLC7A11, SOX4, TBCD, TUFM, USP22 | protein synthesis, cell signaling and interaction, and reproductive system function, | 14 |
Network 3 | ATP6V0B, BHLHE40, COTL1, CYBA, DDIT4, FTL, ITPA, LAPTM5, NEBL, NUDT1, RPS2, S100A11, SORD | genetic disorder, immunological disease and free radical scavenging | 14 |
Network 4 | ANXA2, ARPC1B, BUD31, GNPTG, GPATCH3, GTF3C1, NAP1L4, PHB, POLR2H, PUF60, UBA6, VKORC1, WDR36 | gene expression, cellular development, cellular growth and proliferation | 14 |